ACTIVE LEVELS OF PARAMETERS AFFECTING THE IMMUNE SYSTEM.

Authors

  • Pardaev Erkin Soatovich TMA Termiz branch teacher of the department of anatomy and clinical anatomy
  • Nurova Zamira Annakulovna TMA Termez branch, Department of Medical Biology and Histology, Associate Professor
  • Nazarova Nigora Zikrillaevna TMA, Department of Normal and Pathological Physiology

DOI:

https://doi.org/10.37547/

Keywords:

immuneimmune system, environmental factors, nutrition, stress, activity indicator, sleep, microbiome, resilient, immune response, health.

Abstract

The immune system plays a key role in maintaining the body's homeostasis, providing protection against pathogens, atypical cells, and toxins. Its effectiveness is determined by many factors, including genetic characteristics, lifestyle, nutrition, physical activity level, stress, sleep quality, microbiome influence, age, and environmental exposure. This paper examines the active levels of these parameters and their impact on adaptive and innate immunity. In particular, it analyzes the mechanisms of immunomodulation under the influence of nutrients (vitamins, trace elements, antioxidants), hormonal levels (cortisol, melatonin, sex hormones), inflammatory marker levels, and intestinal microflora. Particular attention is paid to stress-induced changes in the immune system, their connection with chronic inflammatory diseases, and autoimmune processes.

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References

1.Calder, P. C., Carr, A. C., Gombart, A. F., & Eggersdorfer, M. (2020). Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients, 12(4), 1181.https://doi.org/10.3390/nu12041181

2.Furman, D., Campisi, J., Verdin, E., et al. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25, 1822–1832.https://doi.org/10.1038/s41591-019-0675-0

3.Nieman, D. C., Wentz, L. M. (2019). The compelling link between physical activity and the body's defense system. Journal of Sport and Health Science, 8(3), 201–217.https://doi.org/10.1016/j.jshs.2018.09.009

4.Besedovsky, L., Lange, T., & Born, J. (2019). Sleep and immune function. Pflügers Archiv - European Journal of Physiology, 471(3-4), 387–397.https://doi.org/10.1007/s00424-018-2244-x

5.Belkaid, Y., & Hand, T. W. (2014). Role of the microbiota in immunity and inflammation. Cell, 157(1), 121–141.https://doi.org/10.1016/j.cell.2014.03.011

6.Dhabhar, F. S. (2018). The short-term stress response – Mother nature's mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity. Frontiers in Neuroendocrinology, 49, 175–192.https://doi.org/10.1016/j.yfrne.2018.03.004

7.Akdis, M., Aab, A., Altunbulakli, C., et al. (2016). Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. Journal of Allergy and Clinical Immunology, 138(4), 984–1010.https://doi.org/10.1016/j.jaci.2016.06.033

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Published

2025-05-27

How to Cite

ACTIVE LEVELS OF PARAMETERS AFFECTING THE IMMUNE SYSTEM. (2025). International Bulletin of Medical Sciences and Clinical Research, 5(5), 77-80. https://doi.org/10.37547/

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