IMMUNOMORPHOLOGICAL STATES OF THE SPLEEN UNDER THE INFLUENCE OF PATHOLOGICAL FACTORS AND THEIR ADAPTIVE MECHANISMS

Authors

  • Nurova Zamira Annakulovna TMA Termiz branch Head of the Department of Medical Biology and Histology, Associate Professor
  • Khaitov Azizkhon Akhmetovich TMA Termiz branch Department of Pharmacology and Clinical Pharmacology
  • Saidov Shokhrullo Sharofullaevich TMA Termiz branch, Department of Medical Biology and Histology
  • Urazova Zarina Urmanovna Students of TMA Termiz branch
  • Abdurakhmanov Zukhriddin Alisherovich Students of TMA Termiz branch

DOI:

https://doi.org/10.37547/

Keywords:

spleen, immunomorphology, pathological factors, adaptation, lymphoid structures, cytokines.

Abstract

The spleen plays a key role in immune regulation and homeostasis, participating in blood filtration, antigen presentation and formation of an adaptive immune response. The influence of pathological factors, such as infections, autoimmune diseases, hypoxia and toxic lesions, causes complex immunomorphological changes affecting lymphoid structures, vascular bed and stromal elements of the organ. The article discusses the key mechanisms of morphofunctional changes in the spleen, as well as adaptive reactions aimed at compensating for damage and maintaining the immune response.

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References

1.Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. – 10th ed. – Elsevier, 2021.

2.Pabst R. The spleen in lymphocyte migration // Immunological Reviews. – 2021. – Vol. 302, Issue 1. – P. 25–35.

3.Mebius RE, Kraal G. Structure and function of the spleen // Nature Reviews Immunology. – 2020. – Vol. 15, Issue 10. – P. 664–675.

4.Minukhin V.N., Patrushev A.G. Morphological changes in the spleen in infectious diseases // Archives of Pathology. - 2022. - V. 84, No. 3. - P. 52-60.

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Published

2025-05-27

Issue

Vol. 5 No. 5 (2025): International Bulletin of Medical Sciences and Clinical Research

Section

Articles

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How to Cite

IMMUNOMORPHOLOGICAL STATES OF THE SPLEEN UNDER THE INFLUENCE OF PATHOLOGICAL FACTORS AND THEIR ADAPTIVE MECHANISMS. (2025). International Bulletin of Medical Sciences and Clinical Research, 5(5), 75-76. https://doi.org/10.37547/

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