IMMUNOMORPHOLOGICAL STATES OF THE SPLEEN UNDER THE INFLUENCE OF PATHOLOGICAL FACTORS AND THEIR ADAPTIVE MECHANISMS
DOI:
https://doi.org/10.37547/Keywords:
spleen, immunomorphology, pathological factors, adaptation, lymphoid structures, cytokines.Abstract
The spleen plays a key role in immune regulation and homeostasis, participating in blood filtration, antigen presentation and formation of an adaptive immune response. The influence of pathological factors, such as infections, autoimmune diseases, hypoxia and toxic lesions, causes complex immunomorphological changes affecting lymphoid structures, vascular bed and stromal elements of the organ. The article discusses the key mechanisms of morphofunctional changes in the spleen, as well as adaptive reactions aimed at compensating for damage and maintaining the immune response.
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