OVERVIEW OF OPPORTUNISTIC INFECTIONS IN IMMUNOCOMPROMISED CHILDREN: ETIOLOGIES AND CLINICAL CHARACTERISTICS FOR PRACTICAL USE
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Abstract
Opportunistic infections (OIs) continue to be a significant cause of illness and mortality in children with malignant or nonmalignant conditions. OIs are defined as infections caused by bacteria, fungi, viruses, or normally harmless commensal organisms that inhabit the human body, but become pathogenic when the immune system is compromised. They may also present as unusually severe infections from common pathogens. In some cases, an OI can manifest as a life-threatening event at the onset of a primary immunodeficiency syndrome. More commonly, OIs arise as complications from immunosuppressive therapies, prolonged hospitalization, or in children undergoing bone marrow or organ transplants.
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CDC Opportunistic Infections definition. Available at: https://www.cdc.gov/hiv/basics/livingwithhiv/opportunisticinfec-tions.html
De Rosa F.G., Corcione S., Raviolo S., et al. Candidemia, and infections by Clostridium difficile and carbapenemase-producing Enterobacteriaceae: New enteropathogenetic opportunistic syndromes? Infez. Med. 2015;23(2):105–116. [PMID: 26110290]. [PubMed] [Google Scholar]
Nucci M., Queiroz-Telles F., Tobón A.M., Restrepo A., Colombo A.L. Epidemiology of opportunistic fungal infections in Latin America. Clin. Infect. Dis. 2010;51(5):561–570. [http://dx.doi.org/10.1086/655683]. [PMID: 20658942]. [PubMed] [Google Scholar]
Bottieau E. Tropical parasitic diseases and immunosuppression. Clin. Microbiol. Infect. 2014;20(4):277. [http://dx.doi.org/10.1111/1469-0691.12590]. [PMID: 24529256]. [PubMed] [Google Scholar]
Polvi E.J., Li X., O’Meara T.R., Leach M.D., Cowen L.E. Opportunistic yeast pathogens: Reservoirs, virulence mechanisms and therapeutic strategies. Cell. Mol. Life Sci. 2015;72(12):2261–2287. [http://dx.doi.org/10.1007/s00018-015-1860-z]. [PMID: 25700837]. [PMC free article] [PubMed] [Google Scholar]
Lake M.A., Ambrose L.R., Lipman M.C., Lowe D.M. '“Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection. BMC Med. 2016;14:54. [http://dx.doi.org/10.1186/s12916-016-0606-6]. [PMID: 27007918]. [PMC free article] [PubMed] [Google Scholar]
MR B-Lajoie. Incidence and prevalence of opportunistic and other infections and the impact of antiretroviral therapy among HIV-infected children in low- and middle-income countries: A systematic review and meta-analysis. Clin. Infect. Dis. 2016;62(12):1586–1594. [http://dx.doi.org/10.1093/cid/ciw139]. [PMID: 27001796]. [PMC free article] [PubMed] [Google Scholar]
Winthrop K.L., Novosad S.A., Baddley J.W., et al. Opportunistic infections and biologic therapies in immune-mediated inflammatory diseases: consensus recommendations for infection reporting during clinical trials and postmarketing surveillance. Ann. Rheum. Dis. 2015;74(12):2107–2116. [http://dx.doi.org/10.1136/annrheumdis-2015-207841]. [PMID: 26395500]. [PubMed] [Google Scholar]
Ison M.G., Hayden R.T. Adenovirus. Microbiol. Spectr. 2016;4(4) [PMID: 27726766]. [PubMed] [Google Scholar]
Groll A.H., Castagnola E., Cesaro S., et al. Fourth european conference on infections in leukaemia; Infectious diseases working party of the European Group for Blood Marrow Transplantation (EBMT-IDWP); Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC-IDG); International Immunocompromised Host Society (ICHS); European Leukaemia Net (ELN). Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. Lancet Oncol. 2014;15(8):e327–e340. doi: 10.1016/S1470-2045(14)70017-8. [PMID: 24988936]. [PubMed] [CrossRef] [Google Scholar]
Aguilar C., Malphettes M., Donadieu J., Chandesris O., Coignard-Biehler H. Prevention of infections during primary immunodeficiency. Clin. Infect. Dis. 2014;59(10):1462–1470. [PubMed] [Google Scholar]
Wanat K.A., Reid E., Kamiyango W., El-Mallawany N.K., Kovarik C.L. Tumoral bacillary angiomatosis in a child with human immunodeficiency virus. JAMA Dermatol. 2014;150(9):1015–1016. [http://dx.doi.org/10.1001/jamadermatol.2013.9128]. [PMID: 25076357]. [PubMed] [Google Scholar]
Sionean C., Le B.C., Hageman K., et al. HIV Risk, prevention and testing behaviors among heterosexuals at increased risk for HIV infection--National HIV Behavioral Surveillance System, 21 U.S. cities, 2010. MMWR Surveill. Summ. 2014;63(14):1–39. [PMID: 25522191]. [PubMed] [Google Scholar]
Raje N., Dinakar C. Overview of immunodeficiency disorders. Immunol. Allergy Clin. North Am. 2015;35(4):599–623. [Review]. [http://dx.doi.org/10.1016/j.iac.2015.07.001]. [PMID: 26454309]. [PMC free article] [PubMed] [Google Scholar]
Siberry G.K., Abzug M.J., Nachman S., et al. Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: recommendations from the National Institutes of Health, Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. Pediatr. Infect. Dis. J. 2013;32(Suppl. 2):i–KK4. [http://dx.doi.org/10.1097/01.inf.0000437856.09540.11]. [PMID: 24569199]. [PMC free article] [PubMed] [Google Scholar]
Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. John E. Bennett, Raphael Dolin and Martin J. Blaser; 2014. [Google Scholar]
Lanternier F., Tubach F., Ravaud P., et al. Incidence and risk factors of Legionella pneumophila pneumonia during anti-tumor necrosis factor therapy: A prospective French study. Chest. 2013;144(3):990–998. [http://dx.doi.org/10.1378/chest.12-2820]. [PMID: 23744173]. [PubMed] [Google Scholar]
Buzzi E., Manzoni P., Castagnola E., Benjamin D.K., Jr, Beghini R., Dall’agnola A. Candida pneumonia in a term infant after prolonged use of inhaled corticosteroids for bronchopulmonary dysplasia (BPD). Early Hum. Dev. 2013;89(Suppl. 1):S62–S63. [http://dx.doi.org/10.1016/S0378-3782(13)70018-5]. [PMID: 23809354]. [PubMed] [Google Scholar]
Fishman J.A. Infection in solid-organ transplant recipients. N. Engl. J. Med. 2007;357(25):2601–2614. [http://dx.doi.org/10.1056/NEJMra064928]. [PMID: 18094380]. [PubMed] [Google Scholar]
Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am. J. Transplant. 2009;9(Suppl. 3):S1–S155. [http://dx.doi.org/10.1111/j.1600-6143.2009.02834.x]. [PMID: 19845599]. [PubMed] [Google Scholar]