STORAGE CONDITIONS AND SHELF-LIFE DETERMINATION OF THE HEPATOPROTECTIVE HERBAL TEA “HEPAGAL”

Authors

  • Kayumova Guzal Gofur kizi Tashkent Pharmaceutical Institute
  • Kayumov Feruz Sobir ugli Tashkent Pharmaceutical Institute
  • Mamatqulov Zukhriddin Urmonovich Tashkent Pharmaceutical Institute
  • Tukhtayev Hakim Rakhmonovich Tashkent Pharmaceutical Institute

DOI:

https://doi.org/10.37547/

Keywords:

hepatoprotectors, plant raw materials, biologically active substances, assessment of quality indicators, sachet bag, filter tea bag, natural storage conditions, shelf life.

Abstract

This article presents the results of scientific research aimed at determining the shelf life and storage conditions of the “HEPAGAL” herbal tea. The optimal composition and production technology of this hepatoprotective herbal tea, developed on the basis of locally sourced medicinal plant raw materials, were established, and its quantitative and qualitative indicators were evaluated through a comprehensive analysis. At the initial stages of the study, the appearance, color, moisture content, particle-size (fineness) fraction, mass per individual tea bag, and total flavonoid content (expressed as rutin equivalent) of the herbal tea were determined, and the measurement results were recorded. The prepared herbal mixture was packed into filter tea bags approved for use in medical practice and stored under natural conditions, at room temperature, for 30 months. Throughout the storage period, the above-mentioned quality indicators of the herbal tea and the dynamics of the release of biologically active substances into hot water were investigated on a regular basis. The results obtained confirmed the qualitative stability and satisfactory performance of the samples stored in all filter-bag packaging materials. On this basis, the guaranteed shelf life of the “HEPAGAL” hepatoprotective herbal tea was established at 2 years.

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References

1.Abenavoli L., Capasso R., Milic N., Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy Research, 2011, 24, 1423–1432.

2. Sakaeva I.V., Bunyatyan N.D., Kovaleva E.L., Sakanyan E.I., Mitkina L.I., Prokopov I.A., Shelekhina E.S., Mitkina Yu.V. Basic approaches to studying the stability of medicinal products: domestic and international experience. Bulletin of the Scientific Center for Expert Evaluation of Medicinal Products, 2013, No. 3, pp. 8–11.

3. Sakanyan E.I., Shemeryankina T.B., Malkina Yu.K., Lyakina M.N., Postoyuk N.A. Modern approaches to the assessment of the efficacy and safety of medicinal products of plant origin in Russia and abroad. Scientific Center for Expert Evaluation of Medicinal Products, Moscow, 2017, 74 p.

4. Sadikova R.K., Karieva Yo.S., Tashmukhamedova M.A. Determination of the shelf life and storage conditions of capsules based on Samarkand bee balm extract. Pharmaceutical Journal, No. 1, 2024, pp. 48–50.

5. General Pharmacopoeial Monograph (OFS) 1.1.0009.18 – Stability and shelf life of medicinal products. State Pharmacopoeia of the Russian Federation, 14th ed., Moscow, 2018.

6. Korsun V.F., Korsun E.V. Phytotherapy: Traditions of Russian herbalism. Moscow, Eksmo, 2010, 880 p.

7. Moiseev D.V. A new method for determining the shelf life of medicinal plant raw material (leaves of Rhaponticum carthamoides) on the basis of the “accelerated aging” stress test. Recipe, 2012, No. 2, pp. 47–54. URL: https://rucont.ru/efd/.

8. Klintsevich V.N., Bushkevich N.V., Flyurik E.A. Herbal tea: composition, properties, production (a review). Proceedings of BSTU, Series 2, Chemical Technologies, Biotechnology, Geoecology, 2021, No. 1 (241), pp. 5–23. Available from:

https://www.researchgate.net/publication/350337170

9. Abenavoli L., Izzo A.A., Milic N., Cicala C., Santini A., Capasso R. Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytotherapy Research, 2018, 32, 2202–2213.

10. State Pharmacopoeia of the Republic of Uzbekistan. 1st ed., Vol. I, Part 1. Tashkent, 2021, 1216 p.

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Published

2026-05-31

How to Cite

STORAGE CONDITIONS AND SHELF-LIFE DETERMINATION OF THE HEPATOPROTECTIVE HERBAL TEA “HEPAGAL”. (2026). International Bulletin of Medical Sciences and Clinical Research, 6(5), 162-174. https://doi.org/10.37547/

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