STORAGE CONDITIONS AND SHELF-LIFE DETERMINATION OF THE HEPATOPROTECTIVE HERBAL TEA “HEPAGAL”
DOI:
https://doi.org/10.37547/Keywords:
hepatoprotectors, plant raw materials, biologically active substances, assessment of quality indicators, sachet bag, filter tea bag, natural storage conditions, shelf life.Abstract
This article presents the results of scientific research aimed at determining the shelf life and storage conditions of the “HEPAGAL” herbal tea. The optimal composition and production technology of this hepatoprotective herbal tea, developed on the basis of locally sourced medicinal plant raw materials, were established, and its quantitative and qualitative indicators were evaluated through a comprehensive analysis. At the initial stages of the study, the appearance, color, moisture content, particle-size (fineness) fraction, mass per individual tea bag, and total flavonoid content (expressed as rutin equivalent) of the herbal tea were determined, and the measurement results were recorded. The prepared herbal mixture was packed into filter tea bags approved for use in medical practice and stored under natural conditions, at room temperature, for 30 months. Throughout the storage period, the above-mentioned quality indicators of the herbal tea and the dynamics of the release of biologically active substances into hot water were investigated on a regular basis. The results obtained confirmed the qualitative stability and satisfactory performance of the samples stored in all filter-bag packaging materials. On this basis, the guaranteed shelf life of the “HEPAGAL” hepatoprotective herbal tea was established at 2 years.
Downloads
References
1.Abenavoli L., Capasso R., Milic N., Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy Research, 2011, 24, 1423–1432.
2. Sakaeva I.V., Bunyatyan N.D., Kovaleva E.L., Sakanyan E.I., Mitkina L.I., Prokopov I.A., Shelekhina E.S., Mitkina Yu.V. Basic approaches to studying the stability of medicinal products: domestic and international experience. Bulletin of the Scientific Center for Expert Evaluation of Medicinal Products, 2013, No. 3, pp. 8–11.
3. Sakanyan E.I., Shemeryankina T.B., Malkina Yu.K., Lyakina M.N., Postoyuk N.A. Modern approaches to the assessment of the efficacy and safety of medicinal products of plant origin in Russia and abroad. Scientific Center for Expert Evaluation of Medicinal Products, Moscow, 2017, 74 p.
4. Sadikova R.K., Karieva Yo.S., Tashmukhamedova M.A. Determination of the shelf life and storage conditions of capsules based on Samarkand bee balm extract. Pharmaceutical Journal, No. 1, 2024, pp. 48–50.
5. General Pharmacopoeial Monograph (OFS) 1.1.0009.18 – Stability and shelf life of medicinal products. State Pharmacopoeia of the Russian Federation, 14th ed., Moscow, 2018.
6. Korsun V.F., Korsun E.V. Phytotherapy: Traditions of Russian herbalism. Moscow, Eksmo, 2010, 880 p.
7. Moiseev D.V. A new method for determining the shelf life of medicinal plant raw material (leaves of Rhaponticum carthamoides) on the basis of the “accelerated aging” stress test. Recipe, 2012, No. 2, pp. 47–54. URL: https://rucont.ru/efd/.
8. Klintsevich V.N., Bushkevich N.V., Flyurik E.A. Herbal tea: composition, properties, production (a review). Proceedings of BSTU, Series 2, Chemical Technologies, Biotechnology, Geoecology, 2021, No. 1 (241), pp. 5–23. Available from:
https://www.researchgate.net/publication/350337170
9. Abenavoli L., Izzo A.A., Milic N., Cicala C., Santini A., Capasso R. Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytotherapy Research, 2018, 32, 2202–2213.
10. State Pharmacopoeia of the Republic of Uzbekistan. 1st ed., Vol. I, Part 1. Tashkent, 2021, 1216 p.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license:
- Share: Copy and redistribute the material in any medium or format
- Adapt: Remix, transform, and build upon the material for any purpose, including commercially
Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
License URL: https://creativecommons.org/licenses/by/4.0/
Authors retain copyright of their work while granting the journal first publication rights.