This analytical article presented the results of the analysis of literature published on prestigious bases on the antimicrobial activity of biologically active substances. At the same time, the research carried out on the epidemiology, relevance of the occurrence of resistance from the ratio to drugs with existing antibacterial activity is fully explained and we express our deep gratitude to the authors for this information. The results of the analysis of literature data on the antimicrobial activity of natural and synthetic structured substances were also discussed in search of highly effective anti-microbial agents. Thus, the results of the research carried out can be concluded from the analysis as such. In itself, hetero ring-preserving compounds have high activity under in vtiro conditions, requiring in vivo studies based on them. The antimicrobial activity of biologically active substances obtained on the basis of plants is relatively unstable, which makes them the need for modifications.

Medicinal plants, antimicrobial activity, new antimicrobial drugs, problems, Staphylococcus aureus, Pseudomonas aeruginosa, AMR.

Parija, S.C., 2014. Textbook of Microbiology & Immunology, Elsevier Health Sciences.

W.R. Wikoff, A.T. Anfora, J. Liu, P.G. Schultz, S.A. Lesley, E.C. Peters, G. Siuzdak Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc. Natl. Acad. Sci., 106 (2009), pp. 3698-3703

Todar, K., 2009. Todar's Online Textbook of Bacteriology. Kenneth Todar University of Wisconsin-Madison Dept. of Bacterology.

Mostafa M. Ghorab, Aiten M. Soliman, Mansour S. Alsaid, Ahmed A. Askar, Synthesis, antimicrobial activity and docking study of some novel 4-(4,4-dimethyl-2,6-dioxocyclohexylidene) methylamino derivatives carrying biologically active sulfonamide moiety, Arabian Journal of Chemistry, Volume 13, Issue 1, 2020, Pages 545-556, https://doi.org/10.1016/j.arabjc.2017.05.022

Eloff, J.N. Avoiding pitfalls in determining antimicrobial activity of plant extracts and publishing the results. BMC Complement Altern Med 19, 106 (2019). https://doi.org/10.1186/s12906-019-2519-3

Davidson, P. M., Critzer, F. J. & Taylor, T. M. Naturally occurring antimicrobials for minimally processed foods. Ann. Rev. Food Sci. Technol. 4, 163–190 (2013).

Nazir, F. et al. Natural antimicrobials for food preservation. J. Pharmacogn. Phytochem. 6, 2078–2082 (2017).

Giannenas, I., Sidiropoulou, E., Bonos, E., Christaki, E. & Florou-Paneri, P. The history of herbs, medicinal and aromatic plants, and their extracts: past, current situation and future perspectives. In Feed Additives: Aromatic plants and herbs in animal nutrition and health (eds Florou-Paneri, P. et al.) 1–18 (Academic Press, 2020) https://doi.org/10.1017/CBO9781107415324.004.

Balasundram, N., Sundram, K. & Samman, S. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chem. 99, 191–203 (2006).

Chun, S.-S., Vattem, D. A., Lin, Y.-T. & Shetty, K. Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochem. 40, 809–816 (2005).

Gyawali, R. & Ibrahim, S. A. Natural products as antimicrobial agents. Food Control 46, 412–429 (2014).

Poimenidou, S. V. et al. Effect of single or combined chemical and natural antimicrobial interventions on Escherichia coli O157:H7, total microbiota and color of packaged spinach and lettuce. Int. J. Food Microbiol. 220, 6–18 (2016).

Vaou N, Stavropoulou E, Voidarou C, Tsigalou C, Bezirtzoglou E. Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives. Microorganisms. 2021 Sep 27;9(10):2041. doi: 10.3390/microorganisms9102041

Mirzaev Yu.R., Khamraev T.T., Ruzimov E.M., Khamdamov B.N., Abduazimov B.B., Adizov Sh.M., Elmurodov B.J., Yuldashev P.H.. (2022). Study of the effect of alkaloids isolated from the vinca erecta plant on cardiac activity under experimental conditions. Eurasian journal of medical and natural sciences, 2(11), 250–255. https://doi.org/10.5281/zenodo.7220861

Mirzaev Yu.R., Khamroev T.T., Ruzimov E.M., Khamdamov B.N., Abduazimov B.B., Adizov Sh.M., Yuldashev P.Kh., & Elmuradov B.J. (2022). Comparative assessment of acute toxicity of vincanin hydrochloride derivatives in research conditions. International Journal of Medical Sciences And Clinical Research, 2(10), 9–15. https://doi.org/10.37547/ijmscr/Volume02Issue10-03

Yu.R. Mirzаev, T.T. Khamraev, E.M. Ruzimov, Sh.M. Adizov, B.B. Abduazimov, B.N. Khandamov, B.J. Elmurodov, P.H. Yuldashev. (2022). Toxicological characteristics of vincanin hydrochloride and its derivatives in an experimental condition. Eurasian journal of academic research, 2(11), 1027–1033. https://doi.org/10.5281/zenodo.7244593

Yu.R. Mirzaev, T.T. Khamroev, E.M. Ruzimov, B.N. Khamdamov, B.B. Abduazimov, Sh.M. Adizov, P.Kh. Yuldashev, & B.J. Elmuradov. (2022). Evaluation of the effect of vincanin hydrochloride and its derivatives on blood pressure and respiration under experimental conditions. Oriental Journal of Medicine and Pharmacology, 2(04), 1–11. https://doi.org/10.37547/supsci-ojmp-02-04-01

Yu. R. Mirzaev, T. T. Khamroev, E. M. Ruzimov, B. N. Khandamov, & Sh. M. Adizov. (2022). Evaluation of the Effect on the Nervous System of Substances with an Alkaloid Structure Having Antitumor Activity. Journal Healthcare Treatment Development(JHTD) ISSN : 2799-1148, 2(06), 6–10. Retrieved from http://journal.hmjournals.com/index.php/JHTD/article/view/1577

Ashraf A. Mostafa , Abdulaziz A. Al-Askar , Khalid S. Almaary , Turki M. Dawoud , Essam N. Sholkamy , Marwah M. Bakri. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi Journal of Biological Sciences. Volume 25, Issue 2, February 2018, Pages 361-366 https://doi.org/10.1016/j.sjbs.2017.02.004

Sahu JK, Ganguly S, Kaushik A. Synthesis and antimicrobial activity of some novel fused heterocyclic 1,2,4-triazolo [3,4-b][1,3,4] thiadiazine derivatives. J Adv Pharm Technol Res. 2014 Apr;5(2):90-5. doi: 10.4103/2231-4040.133434

Akova M. Epidemiology of antimicrobial resistance in bloodstream infections. Virulence. 2016 Apr 2;7(3):252-66. doi: 10.1080/21505594.2016.1159366

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. VOLUME 399, ISSUE 10325, P629-655, February 12, 2022. DOI:https://doi.org/10.1016/S0140-6736(21)02724-0

Aliev Shavkat Rozimatovich. (2023). Analysis of antimicrobial and antifungal activity of synthetic structural compounds. International bulletin of medical sciences and clinical research, 3(3), 84–90. https://doi.org/10.5281/zenodo.7781219

Aripov A.N, Akhunjanova L.L, Khamroev T.T, Aripov Abdumalik Nigmatovich, Akhunjanova Lola Lazizovna, & Khamroev Tolmas Tolibovich. (2022). Differential Analysis of Chronic Toxic Hepatitis Caused by The Introduction of Heliotrin Solution in Various Ways. Texas Journal of Medical Science, 4, 58–62. Retrieved from https://zienjournals.com/index.php/tjms/article/view/670

Арипов А.Н., Арипов О.А., Ахунджанова Л.Л., Набиев А.Ў., Нишанбаев С.З., Набиева Д.А., Hамроев Т.Т. Тажриба шароитида сафорофлавонолозиднинг гепатотроп фаоллигини ўрганиш. Oriental Journal of Medicine and Pharmacology, 2(02), 55–64. https://doi.org/10.37547/supsci-ojmp-02-02-07

Aripov A.N., Aripov O.A., Akhunjanova L.L., Nabiev A.O., Nabieva D.A., & Khamroev T.T. (2022). Study the antifibrous efficacy of plant proanthocyanidin in rats with chronic heliotrine liver damage. Frontline Medical Sciences and Pharmaceutical Journal, 2(05), 16–25. https://doi.org/10.37547/medical-fmspj-02-05-03.

Aripov A.N., Aripov O.A., Akhunjanova L.L., Nabiev A.O., Nabieva D.A., & Khamroev T.T. (2022). Study the antifibrous efficacy of plant proanthocyanidin in rats with chronic heliotrine liver damage. Frontline Medical Sciences and Pharmaceutical Journal, 2(05), 16–25. https://doi.org/10.37547/medical-fmspj-02-05-03.

Aripov A.N., Aripov O.A., Akhundjanova L.L., Nabiev A.U., Nabieva D.A., & Khamroev T.T. (2022). Study the effect of yantacin on some indicators of cellular renewal and on the level of protein expression on rat hepatocytes in chronic heliotrine liver damage. International Journal of Medical Sciences And Clinical Research, 2(05), 06–13. https://doi.org/10.37547/ijmscr/Volume02Issue05-02.

Т.Т.Ҳамроев, Н.М.Маматқулова, П.А.Нурмахмадова, С.З.Рашидов, И.Т.Абдиназаров, С.Д.Раҳимбоев, Н.Қ.Хидирова, У.М.Якубов. (2022). Adonis turkestanica ўсимлигининг экстракция жараёнида ҳосил бўлган қолдиқ моддаларнинг ўткир заҳарлилиги ва биологик фаоллигини скрининг тадқиқотларда ўрганиш. Eurasian journal of academic research, 2(12), 447–454. https://doi.org/10.5281/zenodo.7332870

Muhammadjonov Bakhriddin Bakhromjon ogli, Ganiev Rustam Ravshan ogli, Nurmetova Yulduz Baltaevna, Madvaliev Baxodirjon Tolibjon ogli, Ilmiyaminov Otabek Alisher ogli, & Khamroev Tolmas Tolibovich. (2022). Evaluation of the Effect of Collecting Plants with Medicinal Properties on the Course of Hemolytic Anemia in the Study Conditions. International journal of health systems and medical sciences, 1(5), 45-51. Retrieved from http://inter-publishing.com/index.php/IJHSMS/article/view/338