PHYTOCHEMICAL PROFILE AND HEPATOPROTECTIVE POTENTIAL OF ROSA CANINA, ORIGANUM TYTTANTHUM, AND CODONOPSIS CLEMATIDEA: A COMPREHENSIVE REVIEW
DOI:
https://doi.org/10.37547/Keywords:
Hepatoprotection, Rosa canina, Origanum tyttanthum, Codonopsis clematidea, Uzbekistan flora, Phytochemistry, Secondary metabolites, Dry extract technology.Abstract
The prevalence of hepatic disorders worldwide necessitates the exploration of potent, bioavailable, and low-toxicity hepatoprotective agents derived from natural sources. Uzbekistan's diverse flora offers a rich repository of medicinal plants with largely untapped pharmacological potential. This review focuses on the phytochemical characterization and synergistic hepatoprotective effects of three distinct species: Rosa canina, Origanum tyttanthum, and the relatively understudied Codonopsis clematidea. Current evidence suggests that the integration of ascorbic acid-rich pseudo-fruits from R. canina, antioxidant-heavy polyphenols from O. tyttanthum, and the unique alkaloid and polysaccharide profile of C. clematidea could provide a superior therapeutic scaffold for liver regeneration. This article evaluates the biochemical mechanisms of these plants, discussing their impact on lipid peroxidation, enzyme activity, and membrane stabilization, ultimately proposing a scientific rationale for their formulation into a standardized dry extract-based dietary supplement.
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References
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