REGENERATIVE PROPERTIES OF PHARMACEUTICAL CREAMS BASED ON CARTHAMUS TINCTORIUS L. EXTRACT: PHARMACOLOGICAL MECHANISMS OF ACTION AND FUTURE PERSPECTIVES
DOI:
https://doi.org/10.37547/Keywords:
Carthamus tinctorius L.; safflower extract; pharmaceutical cream; wound healing; skin regeneration; antioxidant activity; anti-inflammatory activity; flavonoids; topical formulation; regenerative dermatology.Abstract
Carthamus tinctorius, commonly known as safflower, has attracted increasing scientific interest due to its diverse pharmacologically active compounds and broad therapeutic potential in topical pharmaceutical formulations. The plant is rich in flavonoids, phenolic compounds, polyunsaturated fatty acids, hydroxysafflor yellow A, and other bioactive constituents exhibiting antioxidant, anti-inflammatory, antimicrobial, and tissue-regenerative activities. In recent years, pharmaceutical creams containing Carthamus tinctorius L. extract have emerged as promising candidates for the management of skin injuries, inflammatory dermatoses, burns, chronic wounds, and cosmetic skin regeneration.
Downloads
References
1.Dajic-Stevanovic Z, Pljevljakusic D. Safflower (Carthamus tinctorius L.) – forgotten cosmetic plant. In: Proceedings of the Conference on Medicinal and Aromatic Plants. 2012. Available from: https://www.researchgate.net/publication/233808201_Safflower_Carthamus_tinctorius_-_forgotten_cosmetic_plant
2.Kaur M, Sharma A, Singh G. Formulation and evaluation of herbal cream containing safflower extract. Research Journal of Pharmacy and Technology. 2020;13(12):6057–6062. Available from: https://rjptonline.org/AbstractView.aspx?PID=2020-13-12-70
3.Şenyiğit ZA, Karataş A, Arslanoğlu Y. Assessment of commercially safflower oils (Carthami oleum raffinatum) in terms of European Pharmacopoeia criteria and their weight control potentials. Turkish Journal of Pharmaceutical Sciences. 2021;18(6):698–705. Available from: https://turkjps.org/articles/assessment-of-commercially-safflower-oils-carthami-oleum-raffinatum-in-terms-of-european-pharmacopoeia-criteria-and-their-weight-control-potentials/tjps.galenos.2021.84484
4.He Y, Wan H, Du Y, et al. Pharmacological mechanisms and therapeutic potential of hydroxysafflor yellow A in inflammatory and oxidative stress-related diseases. Frontiers in Pharmacology. 2021;12:687389. doi:10.3389/fphar.2021.687389
5.Zhang Y, Liu X, Wang J, et al. Advances in nanoformulations and transdermal delivery systems containing herbal bioactive compounds for regenerative medicine. International Journal of Molecular Sciences. 2024;25(1):1142. doi:10.3390/ijms25011142
6.Asgarpanah J, Kazemivash N. Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L. Chinese Journal of Integrative Medicine. 2013;19(2):153–159. doi:10.1007/s11655-013-1354-5
7.Li X, Bai Y, Yang Y, et al. Anti-inflammatory and antioxidant mechanisms of safflower-derived bioactive compounds in tissue regeneration. Biomedicine & Pharmacotherapy. 2022;154:113546. doi:10.1016/j.biopha.2022.113546
8.Wang H, Chen T, Zhou Q, et al. Emerging transdermal therapeutic systems for plant-derived regenerative compounds. Drug Delivery. 2025;32(1):224–238. doi:10.1080/10717544.2025.2241138
9.Kim JH, Lee SY, Park JH, et al. Therapeutic applications of medicinal plant extracts in dermatological wound healing. Journal of Ethnopharmacology. 2021;280:114443. doi:10.1016/j.jep.2021.114443
10.Zhou X, Tang L, Xu Y, Zhou G, Wang Z. Towards a better understanding of medicinal uses of Carthamus tinctorius L. Evidence-Based Complementary and Alternative Medicine. 2014;2014:857263. doi:10.1155/2014/857263
11.Ahmed N, Rahman S, Karim R. Pharmaceutical cream with Carthamus tinctorius L. extract: formulation and evaluation. Journal of Pharmaceutical Formulation Science. 2025;14(2):88–97. Available from:
12.Müller H, Becker K. Über die Verdaulichkeit von Saflor (Carthamus tinctorius) im frischen und eingesäuerten Zustand bei Schafen. Archiv für Tierernährung. 1987;37(4):321–328. Available from:
13.Rahimov A, Tursunova D, Karimova M. Quantitative composition of flavonoids of Carthamus tinctorius L. and their antioxidant potential. International Journal of Phytochemistry and Pharmacognosy. 2025;9(1):44–52. Available from:
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license:
- Share: Copy and redistribute the material in any medium or format
- Adapt: Remix, transform, and build upon the material for any purpose, including commercially
Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
License URL: https://creativecommons.org/licenses/by/4.0/
Authors retain copyright of their work while granting the journal first publication rights.
