STUDY OF SPECIFIC ANTIMICROBIAL ACTIVITY OF FILM-COATED TABLETS OF CLARITHROMYCIN
DOI:
https://doi.org/10.37547/Keywords:
clarithromycin, antibiotic, film-coated tablets, acute toxicity.Abstract
Research was conducted to assess the specific (antimicrobial) activity of film-coated tablets containing clarithromycin. The results showed that, according to the toxicity classification, this preparation is classified as low-toxic. It was ascertained that the preparation "Clarin" (250 mg and 500 mg) manufactured by Novugen Pharma LLC (Uzbekistan) has comparable specific activity compared to the similar preparation "Claricide" (250 mg and 500 mg) manufactured by Abbott Laboratories Ltd (Pakistan), indicating their biological equivalence.
Downloads
References
1. Sukhanov, M.K., Syabro, M.M. Development of an application for individual dosing of antibiotics// Universum: Technical Sciences. - 2024.-9(4). - P.38-41.
2. Jernberg, C., Lоfmark, S., Edlund, C. et al. Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. ISME J 1, 56-66 (2007). https://doi.org/10.1038/ismej.2007.3
3. Karpov I.A., Kachanko E.F. Clarithromycin: Possibilities of Clinical Use // Medical News.-2012. - No. 1. - P. 68-72.
4. Belenkiy M.L. Elements of Quantitative Assessment of Pharmacological Effect. L., 1963, - P. 81-90.
5. Burbello A.T., Shabrov A.V. Modern Medicines. Moscow. - 2007. - P. 284.
6. Lim S. S., Vos T., Flaxman A. D., et al. A comparative risk assessment of burden
of disease and injury attributable to 67 risk factors and risk factor clusters
in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease
Study 2010 // Lancet.- 2013.- 80. - P.2224-2260.
7. Guskova T.A. Toxicology of preparations. Moscow. 2008. - Pp. 27-30.
8. Guidelines for the study of the general toxic effect of pharmacological substances. /In the Guide to the experimental (preclinical) study of new pharmacological substances. Under the general editorship of Corresponding Member of the PA No. 1, Professor R. U. KHABRIEV. Second edition, revised and supplemented // "Medicine" Publishing House. - 2005. - Pp. 41-54.
9. Максудова Ф.Х., Нусратова Н.Н. Султонова Р.Р Исследование острой токсичности плёночнопокрытых таблеток «Кларин»//Инфекция Иммунитет и Фармакология. Ташкент.- 2026.- №3.С.101-107
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license:
- Share: Copy and redistribute the material in any medium or format
- Adapt: Remix, transform, and build upon the material for any purpose, including commercially
Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
License URL: https://creativecommons.org/licenses/by/4.0/
Authors retain copyright of their work while granting the journal first publication rights.