GENETIC BASIS OF ANTIBIOTIC-RESISTANT BACTERIA

Authors

  • Gulshoda Orifjonova Student of Kokand University, Andijan Branch Lecturer at the Department of Microbiology, Pharmacology, Normal and Pathological Physiology, Kokand University, Andijan Branch
  • Azamat Mo‘minov Student of Kokand University, Andijan Branch Lecturer at the Department of Microbiology, Pharmacology, Normal and Pathological Physiology, Kokand University, Andijan Branch

DOI:

https://doi.org/10.37547/

Keywords:

antibiotic, resistance, resistance genes, PCR, bacteria.

Abstract

This study investigated the genetic basis of antibiotic-resistant bacteria. The antibiotic susceptibility of Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae strains isolated from clinical samples was determined, and the presence of resistance-related genes in their genomes was assessed using the polymerase chain reaction (PCR) method. The results revealed the widespread presence of resistance genes — blaTEM, mecA, vanA, and aac(6’)-Ib — among the bacterial strains. These findings are crucial for understanding the mechanisms of antibiotic resistance and improving strategies for the treatment of infectious diseases.

Downloads

Download data is not yet available.

References

1. CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 30th ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2020.

2. Davies, J., & Davies, D. (2010). Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews, 74(3), 417–433.

3. Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O. (2018). Mobile genetic elements associated with antimicrobial resistance. Clinical Microbiology Reviews, 31(4), e00088-17.

4. Zankari, E. et al. (2012). Identification of acquired antimicrobial resistance genes. Journal of Antimicrobial Chemotherapy, 67(11), 2640–2644.

Downloads

Published

2025-06-17

Issue

Vol. 5 No. 6 (2025): International Bulletin of Medical Sciences and Clinical Research

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license:

  • Share: Copy and redistribute the material in any medium or format
  • Adapt: Remix, transform, and build upon the material for any purpose, including commercially

Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made.

License URL: https://creativecommons.org/licenses/by/4.0/

Authors retain copyright of their work while granting the journal first publication rights.

How to Cite

GENETIC BASIS OF ANTIBIOTIC-RESISTANT BACTERIA. (2025). International Bulletin of Medical Sciences and Clinical Research, 5(6), 43-47. https://doi.org/10.37547/

Similar Articles

1-10 of 57

You may also start an advanced similarity search for this article.