ANTIMICROBIAL ACTIVITY OF 6-AMINOPURINE DERIVATIVES ENCAPSULATED IN NANOSTRUCTURED HYDROGELS
DOI:
https://doi.org/10.37547/Keywords:
nanostructured hydrogel, 6-aminopurine derivatives, antimicrobial activity, controlled release, biomedical materials.Abstract
Nanostructured hydrogels are widely investigated as advanced drug delivery systems due to their high biocompatibility, large water content, and controlled release properties. Incorporation of biologically active purine derivatives such as 6-aminopurine into hydrogel matrices may enhance antimicrobial activity while maintaining a moist environment suitable for tissue regeneration. The present study investigates the antimicrobial activity of 6-aminopurine derivatives encapsulated in nanostructured hydrogels against several pathogenic microorganisms. The results demonstrated that the hydrogel system provided sustained release of the active compound and significantly inhibited microbial growth compared with the control samples. These findings suggest that nanostructured hydrogel systems containing purine derivatives may serve as promising antimicrobial materials for biomedical and pharmaceutical applications.
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