DEPENDENCE OF THE DEVELOPMENT OF CONGENITAL INSUFFICIENCY IN HUMANS ON ONTOPHYLLOGENESIS
DOI:
https://doi.org/10.37547/Keywords:
congenital insufficiency, ontogenesis, phylogenesis, ontophylogenesis, embryonic development, critical periods, genetic factors, epigenetic influence, evolutionary development, morphogenesisAbstract
This article provides a scientific and theoretical analysis of the relationship between the origin and development of congenital malformations in humans and the processes of ontophylogenesis. Based on the laws of ontogenesis and phylogenesis, the influence of morphological and functional changes occurring at the stages of embryonic development on the formation of congenital defects is highlighted. Also, the causes of congenital malformations are revealed based on the integration of critical periods of embryonic development, genetic and epigenetic factors, and environmental influences into the ontogenetic process. The article analyzes the phylogenetic roots of some congenital defects from the point of view of evolutionary development and substantiates their theoretical and practical significance for medical and biological sciences.
Downloads
References
1.Gilbert S.F. Developmental Biology. 11th ed. Sunderland: Sinauer Associates, 2016.
2.Sadler T.W. Langman’s Medical Embryology. 14th ed. Philadelphia: Wolters Kluwer, 2019.
3.Carlson B.M. Human Embryology and Developmental Biology. 6th ed. Elsevier, 2021.
4.Moore K.L., Persaud T.V.N., Torchia M.G. The Developing Human: Clinically Oriented Embryology. 11th ed. Elsevier, 2020.
5.Larsen W.J. Human Embryology. 5th ed. Philadelphia: Churchill Livingstone, 2017.
6.Wolpert L., Tickle C., Arias A.M. Principles of Development. 6th ed. Oxford: Oxford University Press, 2019.
7.Hall B.K. Evolutionary Developmental Biology. 3rd ed. Springer, 2015.
8.Carroll S.B. Endless Forms Most Beautiful: The New Science of Evo-Devo. New York: W.W. Norton, 2005.
9.O‘zbekiston Respublikasi Oliy ta’lim muassasalari uchun “Odam anatomiyasi va embriologiyasi” darsligi. Toshkent, 2020.
10.Xolmatov A., Rahmonov B. Embriologiya asoslari. Toshkent: Fan, 2019.
11.Karimov U. Rivojlanish biologiyasi va ontogenez masalalari. Biologiya va tibbiyot muammolari. 2021;3:45–52.
12.Abduqodirov S. Tug‘ma nuqsonlarning embriologik asoslari. Toshkent: Universitet, 2022.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license:
- Share: Copy and redistribute the material in any medium or format
- Adapt: Remix, transform, and build upon the material for any purpose, including commercially
Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
License URL: https://creativecommons.org/licenses/by/4.0/
Authors retain copyright of their work while granting the journal first publication rights.
