CHANGES IN LIVER STRUCTURE IN OFFSPRING UNDER THE INFLUENCE OF PRENATAL STRESS
DOI:
https://doi.org/10.37547/Keywords:
Cells, prenatal stress, offspring, liver, hepatocytes, morphology, microcirculation, dystrophic changes, oxidative stress, apoptosis, hypothalamic-pituitary-adrenal (HPA) system, embryo.Abstract
Prenatal stress is a psycho-emotional and physiological strain occurring in the maternal organism during pregnancy, significantly affects the development of embryonic organs. This article analyzes morphological and functional changes in the liver tissue of offspring under the influence of prenatal stress. Scientific studies have revealed dystrophic changes in hepatocytes, compaction of sinusoids, impaired microcirculation, and increased markers of oxidative stress. These alterations may lead to disrupted liver development and metabolic dysfunction. Furthermore, elevated levels of glucocorticoids in the maternal organism are shown to program fetal liver development, which may later result in fibrosis, steatosis, and various liver dysfunctions.
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References
1. Junqueira L.C., Carneiro J. Basic Histology: Text & Atlas. McGraw-Hill Education.
2. Kumar V., Abbas A.K., Aster J.C. Robbins and Cotran Pathologic Basis of Disease.
Elsevier.
3. Hall J.E. Guyton and Hall Textbook of Medical Physiology. Elsevier.
4. Sadler T.W. Langman’s Medical Embryology. Wolters Kluwer.
5. Ganong W.F. Review of Medical Physiology. McGraw-Hill.
6. Barker D.J.P. Developmental origins of adult disease (DOHaD theory). David Barker
7. PubMed Central (PMC) maqolalari: Prenatal stress and liver development studies
8.ScienceDirect ilmiy maqolalari: Prenatal stress effects on fetal organs https://www.sciencedirect.com
9. Nature / Springer Open maqolalari: Stress-induced epigenetic changes in liver development
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