SYSTEMATIC REVIEW OF HEPATIC SINUSOIDAL DILATATION IN RODENT FEEDING STUDIES OF GLYPHOSATE-TOLERANT GM CROPS AND ITS TRANSLATIONAL IMPLICATIONS FOR HUMAN LIVER MICROVASCULAR HEALTH
DOI:
https://doi.org/10.37547/Keywords:
hepatic sinusoidal dilatation; glyphosate-tolerant crops; genetically modified organisms; rodent feeding studies; liver microvascular health; translational toxicology; sinusoidal endothelial cells; food safety assessment; histopathology; oxidative stress.Abstract
Hepatic sinusoidal dilatation (HSD) is a histopathological alteration characterized by the widening of hepatic sinusoids and is associated with a range of physiological and pathological conditions, including toxic injury and vascular disturbances. This systematic review evaluates the occurrence of HSD in rodent feeding studies involving glyphosate-tolerant genetically modified (GM) crops and examines its translational relevance for human liver microvascular health. A comprehensive analysis of experimental and regulatory studies reveals that while sinusoidal dilatation has been reported in some rodent models, its frequency, severity, and reproducibility remain inconsistent across studies; in most cases, HSD appears as a mild and isolated finding without clear dose–response relationships or accompanying biochemical evidence of hepatotoxicity, suggesting a predominantly adaptive or incidental nature.
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