INFECTIOUS MONONUCLEOSIS AS A MODEL OF CHRONIC VIRAL INFECTION BASED ON OWN CLINICAL OBSERVATIONS

Authors

  • Kenjaeva Dilorom Toshtemirovna assistant of the department of “Propaedeutics of Childhood Diseases, Childhood Diseases and Pediatrics in the Practice of a Family Doctor” of the Tashkent State Medical University, Termez branch.
  • Akhmadova Durdona Kamol kizi 5th year student of the Tashkent Medical University, Termez branch, Faculty of General Medicine.

DOI:

https://doi.org/10.37547/

Keywords:

infectious mononucleosis, Epstein–Barr virus, chronic infection, lymphotropic viruses, herpes viruses, immunopathogenesis, lymphadenopathy, immune response, cytokines, persistence, EBV-associated tumors.

Abstract

This article examines infectious mononucleosis not only as an acute disease, but also as a unique model of chronic viral infection, which allows us to understand the mechanisms of long-term persistence of the virus in the human body. The work describes in detail the properties of the Epstein-Barr virus, the specifics of its interaction with the immune system, the factors that contribute to the chronicity of the process, as well as the clinical manifestations and complications of the disease. Modern approaches to diagnosis and treatment are presented, and the role of EBV infection in the development of autoimmune diseases and cancer is discussed. It also describes a clinical case of a child with the disease.

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References

1. Burtsev A. A., ed. Clinical Virology. Moscow: GEOTAR-Media, 2021.

2. Kieff E., Rickinson A. Epstein–Barr Virus and Its Diseases. Fields Virology, 2022.

3. Kozlova I. V. Human Herpesvirus Infections. Moscow: Meditsina, 2019.

4. World Health Organization. Global Report on Epstein–Barr Virus Infections and Associated Cancers, Geneva, 2023.

5. Henle G., Henle W. Immunology of Epstein–Barr Virus Infection. J. Infect. Dis., 2021.

6. Romanov A. V. Infectious Diseases. - St. Petersburg: Peter, 2020.

7.Young L. S., Rickinson A. B. Epstein–Barr virus: 50 years on. // Nature Reviews Cancer, 2022.

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Published

2025-10-31

Issue

Vol. 5 No. 10 (2025): International Bulletin of Medical Sciences and Clinical Research

Section

Articles

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How to Cite

INFECTIOUS MONONUCLEOSIS AS A MODEL OF CHRONIC VIRAL INFECTION BASED ON OWN CLINICAL OBSERVATIONS. (2025). International Bulletin of Medical Sciences and Clinical Research, 5(10), 201-204. https://doi.org/10.37547/

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