ALZHEIMER'S DISEASE AND THE MECHANISMS OF MEMORY LOSS
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Abstract
Alzheimer’s disease AD is a chronic neurodegenerative condition characterized by progressive cognitive decline, particularly affecting memory. This disorder involves complex molecular and cellular changes in the brain, including the accumulation of amyloid-beta plaques, abnormal tau protein formations, loss of synaptic connections, oxidative stress, and inflammatory responses. These pathological events disrupt normal neuronal communication and contribute to the gradual deterioration of memory and other cognitive functions. Understanding the mechanisms behind memory impairment in AD is essential for developing new therapeutic approaches and improving patient care. This review summarizes current knowledge on the biological processes that lead to memory loss in Alzheimer’s disease and highlights potential targets for intervention.
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References
1. Karimova, S. (2020). Clinical and morphological characteristics of memory impairment in neurodegenerative diseases. Tashkent: Medical Academy Press.
2. Rasulov, B., & Mamatqulova, G. (2021). Neuronal degeneration and clinical manifestations in Alzheimer’s disease. Andijan Medical Journal, 3(2), 45–52.
3. Sultonov, M. (2019). Pharmacological correction of memory disorders in human brain dysfunction. Kokand: Ilm Ziyo Publishing.
4. Ivanova, L. N., & Petrova, E. A. (2018). Neurobiological foundations of Alzheimer’s disease. Moscow: Nauka Publishing.
5. Kuznetsov, A. P. (2020). Molecular mechanisms of dementia and therapeutic possibilities. Journal of Neuropathology, 12(1), 23–30.
6. Orlova, T. V. (2021). Pathophysiology of memory impairment in Alzheimer’s disease. St. Petersburg: Medical Literature.