В настоящее время РМЖ входит в пятерку наиболее распространенных в мире онкологических заболеваний и лидирует среди причин смерти женщин в возрасте до 50 лет. Выявление РМЖ во время профилактических осмотров в целом по стране остается низким, а показатель запущенности IIIБ - IV ст, который является ведущим критерием качества диагностики, наоборот - высоким. Реальный путь улучшения результатов лечения опухолей молочной железы - ранняя, а в ряде случаев - доклиническая диагностика [1].

Cerebrovascular disease, in particular stroke, ranks first place among the causes of disability. Proper rehabilitation of patients after stroke involves the correction of motor and cognitive impairment, as well as social adaptation. The article discusses the basic principles rehabilitation after a stroke, features of rehabilitation of patients with motor, speech and cognitive impairments. Discussing the use drugs that facilitate the rehabilitation process.

It is known from history that any social system and the development, development and formation of the economy of any country cannot be imagined without taxes and payments, tax policy. In the Kokan khanate, the tax system was closely related to the local government system, and it was one of the important aspects that it was responsible for.

This study assessed the clinical status of patients with unstable angina pectoris with chronic heart failure with preserved left ventricular ejection fraction (CHF–SFV) and its relationship with other factors. This study was conducted on the basis of the Samarkand regional branch of the Republican Specialized Scientific and Practical Medical Center for Cardiology (SRF RSNPMCC). The object of the study was 92 patients aged 45 to 70 years (45 men, 47 women) suffering from coronary heart disease complicated with CHF - SEF stage I-II A, I-III FC. Women with unstable angina pectoris most often suffer from HFpEF , the vast majority of whom have AO. The leading complaint is dyspnea on exertion. With an increase in the total score for SHOKS, the quality of life and exercise tolerance deteriorate. The severity of clinical manifestations of CHF correlates with the degree of LV hypertrophy. Patients with hypertension and coronary artery disease have more pronounced CHF symptoms, tolerate physical activity worse and have a higher degree of LV hypertrophy.

Статья рассматривает общий адаптационный синдром (ОАС) как физиологический ответ организма на стрессорное воздействие. Синдром включает в себя три стадии: аларм, резистентность и истощение. Описываются защитные механизмы организма на первой стадии, приспособление к условиям стресса на второй и возможные осложнения при истощении на третьей. Рассмотрены физические и психические стрессорные воздействия, которые могут вызвать ОАС. Понимание данного синдрома поможет улучшить состояние здоровья и предотвратить возможные осложнения при стрессе. В статье также приведены рекомендации по снижению стресса и укреплению здоровья.

Кариес зубов — это длительный хронический процесс, который является очагом и источником инфекции и аллергизации организма ребенка, так как с пищей ребенок постоянно заглатывает большое количество микроорганизмов и продуктов разложения тканей зуба и пищи, задерживающейся в кариозной полости. Кроме того, эти же микроорганизмы, их токсины и продукты жизнедеятельности всасываются в кровь через слизистую оболочку рта и в местах контакта зуба с челюстью. Такое постоянное инфицирование организма и его сенсибилизация способствуют развитию у детей хронических тонзиллитов, ревматизма, заболеваний почек, суставов, желудочно-кишечного тракта и ослаблению зрения

Mitral valve prolapse continues to arouse considerable interest because of its worldwide prevalence, lack of unanimity in diagnostic criteria, and association with such potentially serious complications as angina-like chest pain, cardiac arrhythmias, sudden death, progressive mitral regurgitation, cerebral embolism, and infective endocarditis. This review includes a discussion of the prevalence of mitral valve prolapse around the world, a critical review of the diagnostic criteria, and a discussion of the pathophysiology of the important complications, with special emphasis on cardiac arrhythmias.

This article discusses the issue of the role of Kyrgyz and Kipchaks in the socio-political life of the Kokhan Khanate.

Mathematics education plays a crucial role in the professional training of medical personnel, providing them with the quantitative skills necessary for accurate diagnosis, effective treatment, and sound decision-making. In the ever-advancing field of medicine, the ability to comprehend, analyze, and interpret numerical data is essential for healthcare professionals to deliver high-quality care and contribute to patient well-being. This article explores the significance of mathematics education in the training of medical personnel, highlighting its applications in various medical disciplines and underscoring the importance of integrating mathematical concepts into the medical curriculum.

In 2017-2022, the state of respiratory tuberculosis was analyzed in 71 students of higher educational institutions located in Surkhandarya region. It has been shown that primary infection with tuberculosis mycobacteria in higher educational institutions can be considered as a risk factor for the subsequent development of the disease. The need for special prevention (BCG revaccination) for students of higher educational institutions, especially in the period of epidemiological problems.

Modern conditions of development of society require further development of the content of vocational education. When studying the content of vocational education, it is necessary to take into account the economic and social development of the country, the requirements of scientific and technological development, the goals and objectives of vocational education, and the strategic directions of vocational education.

Известно, что введение в состав биологически активных препаратов жизненно важных металлов не только уменьшает их вредность, но и в большинстве случаев увеличивает биологическую активность препарата и нередко обнаруживаются новые биологические свойства.

В статье представлен обзор научной литературы, клинических наблюдений, содержащий данные о особенностях неврологических проявлений и психических расстройств, осложнениях со стороны нервной системы при новой коронавирусной инфекции, иллюстрированный клиническими примерами.  Неврологические проявления не лидируют в клинике заболеваний, вызванных коронавирусами. Однако развитие нервной системы возможно и при респираторных, сенсорных, двигательных, вегетативных и других нарушениях центральной и периферической нервной системы.

The aim of this study is to review the prevalence of anatomical variations in sinonasal area, determine their relationship with gender, age and condition of the teeth, as well as to identify clinical significance.

This article describes the organizational issues of musical clubs in general secondary schools. The article highlights the modern requirements for the organization of music clubs in general secondary schools and the important recommendations necessary for music teachers during their activities.

The article reveals the results of a study of the relationship between the genotypes of the CYP2C19 gene in patients with gastric and duodenal ulcers and the manifestation of concomitant diseases. Recommendations are given for the personification of peptic ulcer pharmacotherapy, taking into account genetic markers of pharmacokinetics.

Hemorrhagic vasculitis is the most common group of systematic vasculitis. It is prevalence is 13.5 - 25 cases per 100 thousand population per year. The disease is systemic in nature and is typical for people aged 4 to 12 years. Boys get sick 2-2.5 times more often than girls. Left untreated vasculitis can lead to serious complications. Intestinal and pulmonary bleeding, thrombosis, kidney failure, liver failure, heart attack this is not a complete list of the dangerous consequences of the disease. The main reason is damage to the endothelium. Vasculitis can lead the patient to disability and even death.

In addition to increasing the intellectual potential of students, information and communication technologies, the more effectively we can use them in the field of education, the more media education will improve. This, in turn, increases the professional competence of the pedagogue.

Condylomas are growths of the epithelium that form on the vulva and skin of the perineum (perianal area) as a result of infection with the human papillomavirus (HPV). Other names are also used to refer to this disease: viral papillomas, genital warts, genital warts. The main route of infection transmission is sexual.

Metabolic syndrome (MS) in recent years has attracted more and more attention of doctors around the world, which is associated with its wide distribution, reaching 25-30% in the adult population, and increasing with age [1, 2, 7].

The relevance of the problem of chronic obstructive pulmonary disease (COPD) is due to the prevalence of the disease, high mortality, high economic costs associated with the treatment of patients [1]. The development of inflammation in this disease and its prognosis are largely determined by the state of the immune system.

Проведен анализ  клинического течения гнойных ран с учётом динамики морфологических изменений мягких тканей  на фоне тиреотоксикоза и оценка результатов их лечения. У 104 (10,5%) из 986 пациентов, получавших лечение в клинической базе БухГосМИ был диагностирован тиреотоксикоз. В результате проведенного исследования у пациентов с гнойными хирургическими заболеваниями  на фоне тиреотоксикоза наблюдается сложное своеобразное  клиническое течение  и  приводящее к тяжелым осложнениям. Своевременная коррекция гормональных нарушений при помощи тиреостатиков приводит к лучшим результатам лечения, которые подтверждаются гистологическими и цитологическими исследованиями. Таких пациентов необходимо лечить совместно с эндокринологом.

Myocardial infarction is one of the most important socio-economic problems in the world due to high mortality and disability of the population. Patients who have had myocardial infarction are at increased risk, their life expectancy is half as long, and the incidence of cardiovascular complications and death is significantly higher than in people of the same age without myocardial infarction. The study included 45 men aged 40 to 60 years (49.2±2.5 years) who were admitted to the cardio intensive care unit with a diagnosis of ACS with further transformation into AMI with a Q wave (20 bx) or without a Q wave (20 b -X). The control group consisted of 35 practically healthy men aged 35 to 60 years (47.9±2.5 years). Upon admission to the hospital, patients received standard therapy: for ACS without ST segment elevation - antiplatelet agents (aspirin), anticoagulants (heparin), beta-blockers, ACE inhibitors, nitrates, potassium preparations. In ACS with ST segment elevation, patients underwent thrombolytic therapy for 6 hours , in addition to the generally accepted standard therapy.

Purpose of work - determination of the level of radiological imaging and clinical-laboratory indicators in patients with rheumatoid arthritis depending on the haptoglobin system of different phenotypes.The study was conducted on 214 patients diagnosed with rheumatoid arthritis who were treated in the medical association during 2018-2021. The study used general clinical, medico-social, hematological, biochemical, immunological, instrumental and statistical research methods. All patients with RA according to hematological parameters were divided into 2 groups: 50 (23.4%) patients without anemia, who made up our control group; the remaining 164 (76.6%) patients were diagnosed with anemia by hematological parameters, these patients constituted the main group. The type and degree of anemia in RA patients was determined in accordance with the classification recommended by WHO. ACD was observed in 94 (57.3%) patients, IDA in 65 (39.6%) patients, and 5 patients (3.1%) had both ACD and IDA. 76.6% of all RA patients participating in the study were diagnosed with anemia of various forms and degrees, which are characterized by a relationship between the duration, activity and radiographic manifestations of the disease

Стационарное лечение острого орхоэпидидимита у людей с сахарным диабетом требует выбора довольно четкой и целесообразной тактики с целью купирование инфекционного процесса в краткие сроки, не допуская возникновение грозных осложнений для ослабленного организма пациента. Мы описали собственную практику введение пациентов данной категории и делимся полученными результатами.

At present, the use of enzyme preparations is an integral part of most industrial and agricultural processes.

The article provides an analysis of the scientific literature on the concept of "professional stress" and the reason for its occurrence in the activities of a general practitioner, indicating the need for further research in this area. The causes of professional stress in the activities of a general practitioner are widely covered. Identification of the causes of professional stress in the activities of a general practitioner can become the basis for the development of additional criteria for its prevention.

This article examines the issues of developing the teacher's spiritual image. In addition, the important components of the development of the spiritual image of the teacher are covered in detail.

This article discusses the role of reading in the formation of the spiritual and moral worldview of teenage girls. The authors explore the ways in which exposure to different perspectives, positive role models, ethical dilemmas, and opportunities for reflection can contribute to the development of their values and beliefs. The article includes a literature analysis of previous research and studies on the topic, as well as recommendations for books that may be particularly helpful for teenage girls in this process. The authors conclude that reading can be a valuable tool in the formation of the spiritual and moral worldview of teenage girls, but caution that it is not a substitute for other forms of support and guidance, such as therapy or counseling. Overall, this article provides insights into how parents, educators, and other caregivers can use reading to promote the growth and development of teenage girls.

this article shows pollution by plastic waste, which is one of the most urgent problems today, and its level of damage to the environment and living organisms, including the human body. In addition, the serious harm of microplastics is also covered.

Приведены данные по изучению микронутриентного состава растения Capsella bursa - pastoris. Изучением микронутриентного состава показано, что среди исследованных макро-микро элементов основными являются K, Ca, Na, Mg, Fe и Ba. При анализе их количества содержание макроэлементов в стеблях растения пастушьей сумки составляет 3,6% и из них калия-2,9%, далее кальций, натрий и магний 0,4%, 0,2% и 0,1% соответственно. Содержание микроэлементов отличается от разных видов вегетативных органов растения.

The aim of the study was to study the results of surgical treatment of patients with cavity formations of the liver with complex intrahepatic locations with small sizes. According to a number of modern authors, such diseases as parasitic and non-parasitic cysts, residual liver cavities after surgery and liver abscess can be included in the category of cavitary liver formations. With complex intrahepatic locations of cavitary formations of the liver, especially its small size, surgical treatment has a number of technical difficulties.

Проведено анализ результатов хирургического лечения у 22 больных c полостными образованиями печены II группы у 11 отмечались полостного образования с небольшими размерами  внутрипеченочного расположениям в II – VI сегментах печены. Из 11 данных категории больных 7 пациенты были гидатывной эхинококкозом печены, 4 пациенты были остаточными полостями после перенесенного операции эхинакокэктомии в течении последних 3 года.

В женской популяции сердечно сосудистые заболевания и рак молочной железы действительно имеют общие модифицируемые факторы риска. Это определяет перспективы дополнительных преимуществ немедикаментозных профилактических мероприятий. В Статье рассматривается что при раке молочной железы мы все еще не располагаем недостаточными данными об эффективности тех или иных профилактических вмешательств, ориентированных на обсуждаемые факторы риска.

Исследовано влияние на кинетику полимеризaции и сополимеризaции тетрафторэтилена(ТФЭ) с гексафторпропиленом(ГФП) температуры, концентрaции низкотемпературного инициатора – диизопропилпероксидикарбоната, продолжительности реакции, соотношения мономеров в исходной смеси, а также наличие в системе  органических жидкостей.

Заболевания прямой и ободочной кишки изучались врачами с древних времен, и в каждом дошедшем до нас руководстве по медицине данной патологии уделялось внимание и во всем мире проводятся многочисленные научные изыскания для решения этой глобальной проблемы. Одним из направлений дальнейшего совершенствования техники хирургических вмешательств и улучшения функциональных результатов после них, является углубленное изучение анатомо-функциональных особенностей толстой кишки, использование выявленных закономерностей при выполнении стандартных радикальных, восстановительных и реконструктивно - восстановительных операций. Из-за гуманитарных соображений проведение экспериментов на человеческий организм ограничено, возникает необходимость использования белых лабораторных крыс как альтернативу. В научно-исследовательском процессе медицинских учебных заведений для моделирования ряда процессов человеческого организма широко используют белых лабораторных крыс.

The existing structure of the system for ensuring unity is included: the ministry of information technologies and communications of the Repulic of  Uzbekistan is a basic metrological service for the cube unicon.uz Technical Committee for  Standardization in the Field of Telecommunications and Postal Communications The State Inspection of Communications of Metrological Services and responsible for the state of measuring instruments of economic entities.

Non-alcoholic fatty liver disease (NAFLD) - common chronic liver disease, characterized by pathological accumulation of fat droplets, not associated with alcohol. NAFLD is often a component of other diseases such as metabolic syndrome, diabetes, obesity, and contributes to the prevalence of CVD among the population. In the early stages of the NAFLD are characterized by ineffectiveness of specific treatment and progressive progression of the disease due to the nonspecific clinical signs.

The chemical industry is a basic industry that is closely interconnected with all sectors of the economy. The industry's production should be based on high technologies, and the products manufactured according to the nomenclature should meet international standards. Therefore, the development of the chemical industry is a priority task of the modern development of the economy of the Republic of Uzbekistan.