IMMUNOMORPHOLOGICAL STATES OF THE SPLEEN UNDER THE INFLUENCE OF PATHOLOGICAL FACTORS AND THEIR ADAPTIVE MECHANISMS
Article Sidebar
Main Article Content
Abstract
The spleen plays a key role in immune regulation and homeostasis, participating in blood filtration, antigen presentation and formation of an adaptive immune response. The influence of pathological factors, such as infections, autoimmune diseases, hypoxia and toxic lesions, causes complex immunomorphological changes affecting lymphoid structures, vascular bed and stromal elements of the organ. The article discusses the key mechanisms of morphofunctional changes in the spleen, as well as adaptive reactions aimed at compensating for damage and maintaining the immune response.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
References
1.Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. – 10th ed. – Elsevier, 2021.
2.Pabst R. The spleen in lymphocyte migration // Immunological Reviews. – 2021. – Vol. 302, Issue 1. – P. 25–35.
3.Mebius RE, Kraal G. Structure and function of the spleen // Nature Reviews Immunology. – 2020. – Vol. 15, Issue 10. – P. 664–675.
4.Minukhin V.N., Patrushev A.G. Morphological changes in the spleen in infectious diseases // Archives of Pathology. - 2022. - V. 84, No. 3. - P. 52-60.