VITAMIN THERAPY IN LIVER CIRRHOSIS WITH SPECIAL EMPHASIS ON NEUROVITAN: PATHOPHYSIOLOGY, CLINICAL APPLICATION, AND REGIONAL PRACTICE (UZBEKISTAN EXPERIENCE)
DOI:
https://doi.org/10.37547/Keywords:
liver cirrhosis, vitamin therapy, Neurovitan, B-complex vitamins, hepatic encephalopathy, Uzbekistan, Andijan, alcoholic liver diseaseAbstract
Liver cirrhosis is a chronic progressive liver disease characterized by diffuse fibrosis, regenerative nodules, and irreversible destruction of normal hepatic architecture. It remains a major global and regional public health problem, including in Uzbekistan, where viral hepatitis B and C and alcohol-related liver disease are the leading causes. Nutritional deficiencies, particularly of B-group vitamins, are highly prevalent in cirrhotic patients and significantly contribute to neurological, metabolic, hematological, and immunological dysfunction.
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References
1.European Association for the Study of the Liver. EASL Clinical Practice Guidelines for decompensated cirrhosis. J Hepatol. 2018.
2.AASLD Practice Guidance on Cirrhosis Management. Hepatology. 2023–2025.
3.World Gastroenterology Organisation. Global Guidelines: Cirrhosis. 2023.
4.O'Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Hepatology. 2010.
5.Butterworth RF. Thiamine deficiency and brain disorders. Nutr Res Rev. 2013.
6.Plauth M et al. ESPEN guideline on clinical nutrition in liver disease. Clin Nutr. 2019.
7.Bemeur C, Butterworth RF. Nutrition in cirrhosis and hepatic encephalopathy. Clin Liver Dis. 2016.
8.Mendenhall CL et al. Protein-calorie malnutrition in cirrhosis. Am J Clin Nutr. 1995.
9.Morgan MY. The treatment of hepatic encephalopathy. Metab Brain Dis. 2016.
10.Askarov IR. Clinical and biochemical aspects of hepatology in Uzbekistan. Andijan. 2022.
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