«THE ROLE OF THE NASOPHARYNGEAL MICROBIOTA IN THE PREDISPOSITION TO CHRONIC SINUSITIS»
DOI:
https://doi.org/10.37547/Keywords:
Nasopharyngeal microbiota; Dysbiosis; Chronic sinusitis; 16S rRNA sequencing; Metagenomics; Immune regulation; Probiotics; ENT disorders.Abstract
The nasopharyngeal microbiota plays a critical role in maintaining upper respiratory tract health by protecting the mucosa from pathogenic microorganisms and regulating local immune responses. Dysbiosis, characterized by an imbalance between beneficial and pathogenic microorganisms, increases susceptibility to chronic sinusitis by promoting inflammation and recurrent disease. Modern molecular techniques, including 16S rRNA sequencing, metagenomic, metatranscriptomic, and metabolomic analyses, enable comprehensive characterization of microbial communities, identification of dysbiosis, and prediction of disease risk. Understanding the composition and function of the nasopharyngeal microbiota offers opportunities for early diagnosis, personalized preventive strategies, and potential prognostic markers in chronic sinusitis. Systematic investigation of these microbial communities represents a promising direction for improving the prevention and management of chronic ENT disorders.
Downloads
References
1.Man, W.H., de Steenhuijsen Piters, W.A.A., & Bogaert, D. (2017). The microbiota of the respiratory tract: Gatekeeper to respiratory health. Nature Reviews Microbiology, 15, 259–270.
2.De Boeck, I., Wittouck, S., Wuyts, S., et al. (2020). Recent advances in understanding the respiratory microbiota in health and disease. FEMS Microbiology Reviews, 44(2), 259–280.
3.Abreu, N.A., Nagalingam, N.A., Song, Y., et al. (2012). Sinus microbiome diversity depletion and chronic rhinosinusitis. mBio, 3(1), e00188–12.
4.Ramakrishnan, V.R., Hauser, L.J., & Frank, D.N. (2019). The sinonasal microbiome in health and disease. Current Opinion in Otolaryngology & Head and Neck Surgery, 27(1), 28–34.
5.Fokkens, W.J., Lund, V.J., Hopkins, C., et al. (2020). European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology, 58(Suppl S29), 1–464.
6.Orlandi, R.R., Kingdom, T.T., Hwang, P.H., et al. (2016). International consensus on diagnostic criteria for chronic rhinosinusitis. International Forum of Allergy & Rhinology, 6(Suppl 1), S22–S23.
