AYOLLAR ICHKI TANOSIL A’ZOLARINING EMBRIONAL RIVOJLANISHI VA TUG’MA ANOMALIYALARINING ANATOMIK-KRITIK TAHLILI
Article Sidebar
Main Article Content
Abstract
Mazkur ilmiy maqola ayollar ichki tanosil a’zolarining tuxumdonlar, bachadon naylari, bachadon va qinning yuqori qismining embrional rivojlanish jarayonlarini chuqur anatomik va embriologik tahlil qilishga bag‘ishlangan. Tadqiqotda jinsiy differensiyalanishning erta embrional bosqichlarida Müller (paramesonefrik) yo‘llarining shakllanishi, migratsiyasi, birlashuvi va segmentatsiyasi bilan bog‘liq murakkab morfogenetik mexanizmlar tizimli ravishda ko‘rib chiqiladi. Ushbu jarayonlarning genetik, molekulyar va atrof-muhit omillari ta’sirida buzilishi natijasida yuzaga keladigan tug‘ma anomaliyalar anatomik jihatdan tanqidiy baholanadi. Xususan, bachadonning ikki shoxli, septali, bir shoxli shakllari, bachadon va qinning aplaziyasi hamda gipoplaziyasi kabi nuqsonlarning embrional kelib chiqishi, morfologik o‘zgarishlari va klinik ahamiyati tahlil qilinadi. Maqolada tug‘ma anomaliyalarning reproduktiv salomatlikka, homiladorlik kechishiga va perinatal natijalarga ta’siri ilmiy asoslangan holda yoritilib, ularni erta aniqlash va individual yondashuv asosida davolash strategiyalarini takomillashtirish zarurati asoslab beriladi.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
References
1.Sadler T.W. Langman’s Medical Embryology. 14th ed., Philadelphia: Wolters Kluwer, 2019.
2.Moore K.L., Persaud T.V.N., Torchia M.G. The Developing Human: Clinically Oriented Embryology. 11th ed., Elsevier, 2020.
3.Rock J.A., Jones H.W. Te Linde’s Operative Gynecology. 12th ed., Wolters Kluwer, 2020.
4.Acien P., Acien M. The presentation and management of complex female genital malformations. Human Reproduction Update, 2016.
5.Grimbizis G.F., et al. The ESHRE/ESGE consensus on the classification of female genital tract congenital anomalies. Human Reproduction, 2013.
6.Oppelt P., et al. Female genital malformations and their associated abnormalities. Fertility and Sterility, 2007.
7.Kobayashi A., Behringer R.R. Developmental genetics of the female reproductive tract. Current Topics in Developmental Biology, 2003.
8.Biason-Lauber A., et al. Genetic basis of MRKH syndrome. Human Genetics, 2004.
9.Bouchard M., et al. Genetic regulation of Müllerian duct development. Developmental Biology, 2009.
10.Speroff L., Fritz M.A. Clinical Gynecologic Endocrinology and Infertility. 9th ed., Lippincott Williams & Wilkins, 2020.
11.Cunningham F.G., et al. Williams Obstetrics. 26th ed., McGraw-Hill, 2022.
12.Standring S. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 42nd ed., Elsevier, 2021.
13.Miller R. Development of the Female Reproductive System and Its Disorders. Journal of Reproductive Medicine, 2017.
14.Templeton A. Congenital Anomalies of the Female Genital Tract: Etiology and Clinical Implications. Obstetrics and Gynecology Clinics, 2014.
15.Heinonen P.K. Congenital Malformations of the Female Reproductive Tract. Obstetrics and Gynecology, 2003.
16.Leroy C., et al. Impact of Müllerian Duct Development and Disorders on Female Reproductive Health. Human Reproduction, 2015.
17.O'Rahilly R., Müller F. Developmental and Clinical Anatomy of the Female Reproductive System. Wiley-Blackwell, 2006.
18.Zhao X., et al. Müllerian Duct Development: Genetic and Molecular Mechanisms. Human Molecular Genetics, 2011.
19.Pavone M.E., et al. Management of Female Genital Tract Anomalies: A Multidisciplinary Approach. Fertility and Sterility, 2020.
20.Dunlap C., et al. Embryology of the Female Reproductive System: Molecular Mechanisms and Clinical Insights. Journal of Obstetrics and Gynecology, 2018.