Secondary infertility is one of the main indications for in vitro fertilization (IVF). Lack of preconceptional preparation has been associated with significantly higher reproductive risks, ranging from infertility to intrauterine structural defects and diseases . We studied the microelement composition of the blood and follicular fluid of women with tubal infertility.  During the study of the microelement composition of peripheral blood, Zinc deficiency was determined in 28% of women and Iron deficiency in 7.14% of women. At the same time, the microelement composition of the follicular fluid was studied and it was determined that zinc was consumed 69% of the initial value. And also the concentration of iron and copper is reduced to 32% and 11.2% accordingly . In this review, we focus on the reproductive risks associated with certain preconception care, which is a critical step in determining fetal development and health due to the potential onset of a number of diseases in women with tubal infertility.

infertility, in vitro fertilization, preconception preparation, folic acid

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