Articles
| Open Access | CHEMICAL CONSTITUENTS OF THE ROOTS OF FERULA SAMARKANDICA KOROVIN (OQ CHAIR) ANNOTATION
H.Meliyev , Namangan Institute of Engineering and Technology Kh.Sh.Kamoldinov , Chinese Academy of Sciences Xinjiang Institute of Physics and Chemical Technology A.Dj.Kurbanova , Chirchik State Pedagogical University R.N.Rakhimov , Institute of Bioorganic chemistry, Academy of Sciences of UzbekistanAbstract
Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of ten known sesquiterpenoid coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively.
Keywords
UV, HPLC, Ferula samarkandica, coumarin, badrakemin, feshurin, neveskin, samarkandin, kovrak, BAA.
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