MODERN ANALYTICAL APPROACHES FOR STANDARDIZATION OF “VIGITRIL” SUSPENSION BASED ON BISMUTH AND HISTIDINE

Abstract

This article presents a comprehensive pharmaceutical and analytical investigation of “Vigitril” suspension developed on the basis of bismuth, histidine, and ethylenediaminetetraacetic acid. The study focuses on modern methods of standardization, physicochemical characterization, quality assessment, and stability evaluation of the suspension dosage form. Modern spectrophotometric and chromatographic methods were applied for qualitative and quantitative determination of active pharmaceutical ingredients. Particular attention was devoted to validation parameters including specificity, precision, repeatability, and linearity of analytical procedures. The obtained results demonstrated that the developed suspension possesses satisfactory physicochemical stability, low toxicity, and promising therapeutic effectiveness. The study confirms the pharmaceutical potential of “Vigitril” suspension as a перспективный gastroprotective preparation suitable for further industrial development and clinical application.