THE ETIOLOGICAL IMPORTANCE OF HELICOBACTER PYLORI IN THE DEVELOPMENT OF DUODENAL ULCER DISEASE

Main Article Content

Usanova Saodat Turayevna

Abstract

Gastric and duodenal ulcers are among the most common diseases of the digestive system. Helicobacter pylori is a spiral-shaped, gram-negative bacterium that infects various areas of the stomach. and duodenum . Many cases of gastric ulcers and duodenum , gastritis, duodenitis , stomach cancer and possibly some cases of gastric lymphoma etiologically associated with Helicobacter infection pylori . For decades, increased gastric acidity was considered the main factor associated with the development of peptic ulcers. However, in recent years, increasing attention has been paid to the role of the Helicobacter pylori bacteria. pylori in the genesis of this disease. The treatment of patients with duodenal ulcers remains a pressing issue in practical surgery. This is due to the fact that gastric and duodenal ulcers remain one of the most common diseases in humanity.

Downloads

Download data is not yet available.

Article Details

Section

Articles

How to Cite

THE ETIOLOGICAL IMPORTANCE OF HELICOBACTER PYLORI IN THE DEVELOPMENT OF DUODENAL ULCER DISEASE. (2025). International Bulletin of Medical Sciences and Clinical Research, 5(11), 85-90. https://doi.org/10.37547/

References

1.Atherton, J. C., & Blaser, M. J. (2009). Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. Journal of Clinical Investigation, 119(9), 2475–2487. https://doi.org/10.1172/JCI38605

2.Chey, W.D., Wong, B.C.Y., & American College of Gastroenterology. (2007). American College of Gastroenterology guideline on the management of Helicobacter pylori infection. The American Journal of Gastroenterology, 102(8), 1808–1825. https://doi.org/10.1111/j.1572-0241.2007.01393.x

3.Gisbert, J. P., Calvet, X., & Gomollón , F. (2004). Helicobacter pylori eradication therapy: A systematic review of meta-analyses. European Journal of Gastroenterology & Hepatology, 16(9), 935–945. https://doi.org/10.1097/00042737-200409000-00019

4.Graham, D. Y., Lew, G. M., Malaty, H. M., Evans, D. G., Evans, D. J., Klein, P. D., & Alpert, L. C. (1992). Factors influencing the eradication of Helicobacter pylori with triple therapy. Gastroenterology, 102(2), 493–496. https://doi.org/10.1016/0016-5085(92)90009-4

5.Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006). Pathogenesis of Helicobacter pylori infection. Clinical Microbiology Reviews, 19(3), 449–490. https://doi.org/10.1128/CMR.00054-05

6.Malfertheiner , P., Megraud , F., O'Morain , CA, Gisbert, JP, Kuipers, EJ, Axon, AT, ... & European Helicobacter and Microbiota Study Group and Consensus panel. (2017). Management of Helicobacter pylori infection—the Maastricht V/Florence consensus report. Gut, 66(1), 6–30. https://doi.org/10.1136/gutjnl-2016-312288

7.Smythies, L. E., Waites, K. B., Lindsey, J. R., Harris, P. R., Ghiara , P., & Smith, P. D. (2004). Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in mice deficient in interleukin-10. Infection and Immunity, 68(7), 3585–3591. https://doi.org/10.1128/IAI.68.7.3585-3591.2000

8.Suerbaum, S., & Michetti, P. (2002). Helicobacter pylori infection. New England Journal of Medicine, 347(15), 1175–1186. https://doi.org/10.1056/NEJMra020542

9.World Health Organization (WHO). (2017). Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. Retrieved from https://www.who.int/news-room/detail/27-02-2017

10.Yamaoka, Y. (2010). Mechanisms of disease: Helicobacter pylori virulence factors. Nature Reviews Gastroenterology & Hepatology, 7(11), 629–641. https://doi.org/10.1038/nrgastro.2010.154

Similar Articles

You may also start an advanced similarity search for this article.