CHARACTERISTIC CHANGES IN IRON METABOLISM IN SINUSITIS
DOI:
https://doi.org/10.37547/Keywords:
sinusitis, iron metabolism, inflammation, hepcidin, cytokines, iron deficiency, anemia, chronic sinusitis, pathogenesis, immune response.Abstract
Specific changes in iron metabolism during sinusitis are closely linked to the body's response to the inflammatory process. Inflammation of the paranasal sinus mucosa leads to functional changes in the absorption, transport, and storage of iron. Under the influence of inflammatory mediators, particularly cytokines, hepcidin levels rise, which in turn reduces iron absorption from the intestines and enhances its accumulation in macrophages. Consequently, serum iron levels decrease, potentially leading to functional iron deficiency.
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1.Fokkens W., Lund V., Mullol J. Rhinosinusitis va burun poliplari guruhi bo'yicha Evropa pozitsiyasi qog'ozi. Rinosinusit va burun poliplari bo'yicha Evropa pozitsiyasi // Rinol. Suppl. - 2007. - No 20. - B. 1–136.
2.Strachunskiy L. S., Tarasov A. A., Kryukov A. I. va boshqalar O'tkir bakterial rinosinusitning qo'zg'atuvchisi. SSSR ko'p markazli mikrobiologik tadqiqot natijalari // Klin. Mikrobiol. Mikroblarga qarshi kimyoterapiya - 2005. - No 7 (4). — 337–349-betlar.
3.Sclafani E. P., Dileski R. A., Pitman M. J., Shantz S. P. va boshqalar Umumiy otorinolaringologiya - bosh va bo'yin jarrohligi: 2 jildda / trans. ingliz tilidan Yu. K. Yanovning umumiy tahriri ostida. - M.: Panfilov nashriyoti, 2017. - T. 1. - 736 b.
4.Smith, K. A., & Orlandi, R. R. (2018). Endoscopic sinus surgery outcomes. Current Opinion in Otolaryngology, 26(1), 1–6.
5.Pleis, J. R., & Ward, B. W. (2013). National health statistics report on sinusitis prevalence. CDC Reports, 12, 1-8.
6.Hastan,D., Fokkens, W. J., Bachert, C., et al. (2011). Chronic rhinosinusitis prevalence study. Allergy, 66(9), 1216–1223.
7.Chow, A. W.,Benninger, M. S.,Brook, I., et al. (2012). IDSA clinical guideline for acute bacterial sinusitis. Clinical Infectious Diseases, 54(8), e72–e112.
8.Harvey, R., Hannan, S. A., Badia, L., & Scadding, G. (2010). Nasal saline irrigations for sinusitis. Cochrane Database of Systematic Reviews, 3, CD006394
