MORPHOMETRIC INDICATORS OF THE PROSTATE GLAND AFTER HORMONAL THERAPY IN EXPERIMENTAL INTESTINAL SCAR PROCESSES
DOI:
https://doi.org/10.37547/Keywords:
Prostate gland, morphometry, hormonal therapy, intestinal scar process, experimental model, histology, stromal remodelingAbstract
The relationship between chronic peripheral pathological processes and secondary structural changes in endocrine-sensitive organs remains underexplored in experimental morphology. The present manuscript examines morphometric indicators of the prostate gland after hormonal therapy in an experimental model of intestinal scar formation. The working hypothesis is that chronic scar-associated inflammation and dysregulated neuroendocrine signaling contribute to measurable remodeling of prostatic acini and stromal compartments, while appropriately selected hormonal therapy may partially normalize these changes. Adult male laboratory animals were divided into control, scar model, and scar model with hormonal correction groups. After model induction and treatment, prostate tissue was processed for histological staining and morphometric analysis, including acinar area, epithelial height, stromal fraction, glandular lumen ratio, and vascular density. Illustrative comparative analysis demonstrates that the scar model is associated with decreased acinar dimensions, relative stromal expansion, and epithelial flattening. Hormonal therapy produced partial restoration of acinar geometry and epithelial trophic parameters, with a trend toward normalization of stromal proportion.
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