QANDLI DIABETDA UGLEVOD, LIPID VA OQSIL ALMASHINUVINING BUZILISHLARI. DIABETIK KETOATSIDOZ
DOI:
https://doi.org/10.37547/Keywords:
Qandli diabet, uglevod almashinuvi, lipid almashinuvi, oqsil almashinuvi, insulin yetishmovchiligi, giperglikemiya, lipoliz, keton tanachalari, metabolik asidoz, diabetik ketoatsidoz.Abstract
Ushbu maqolada qandli diabetda uglevod, lipid va oqsil almashinuvidagi o‘zgarishlar hamda ushbu metabolik buzilishlarning diabetik ketoatsidoz rivojlanishidagi roli yoritilgan. Insulin yetishmovchiligi yoki insulin ta’sirining pasayishi natijasida uglevod almashinuvi buzilib, giperglikemiya va hujayra darajasida energiya tanqisligi yuzaga keladi. Buning oqibatida lipid almashinuvi faollashib, yog‘ to‘qimasida lipoliz kuchayadi va jigarda keton tanachalarining ortiqcha hosil bo‘lishi kuzatiladi. Keton tanachalarning to‘planishi metabolik asidoz rivojlanishiga olib kelib, diabetik ketoatsidozning asosiy patogenetik mexanizmini tashkil etadi. Shu bilan birga, oqsil almashinuvidagi o‘zgarishlar mushak to‘qimasida proteolizning kuchayishi va glyukoneogenez jarayonining faollashuvi bilan namoyon bo‘ladi, bu esa giperglikemiyani yanada og‘irlashtiradi. Maqolada ushbu metabolik buzilishlarning o‘zaro bog‘liqligi va ularning qandli diabetning og‘ir asoratlaridan biri bo‘lgan diabetik ketoatsidoz rivojlanishidagi ahamiyati tahlil qilingan.
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