
EFFECT OF HYPOGLYCEMIC COLLECTION ON ENZYME ACTIVITY AND INTENSITY OF GLUCONEOGENESIS UNDER CONDITIONS OF EXPERIMENTAL DIABETES.
G.Yu.Malikova , Tashkent Pharmaceutical InstituteAbstract
The activity of tissue enzymes - hexokinase and phosphorylase in the liver and muscle tissue and the effect of collection on the rate of formation of glucose from its precursors under conditions of hyperglycemia of alloxan origin in the liver were studied. The results of the study of the hypoglycemic properties of the herbal preparation are presented. The main links of glucose metabolism in the liver and muscles under conditions of experimental diabetes under the influence of the collection were studied with a simultaneous comparison with the effect of insulin on these processes.
Keywords
antidiabetes, toxicity, insulin, gluconeogenesis, experimental, intact, hyperglycemia, adenylate cyclase, glucose diabetes mellitus, alloxan mellitus, phosphorylase, hesokinase, enzyme, alloxan hydrate, decapitation, Fiske-Subbaru, liver, skeletal muscle, glycolysis.
References
S.A. Grashchenkova, A.A. Tsurkan, A.V. Gergel. "Influence of white mulberry leaf extract on glycemia in rats against the background of an experimental model of type 2 diabetes mellitus" Integration of education, science and production in pharmacy. Scientific and practical conference. T.-2012. –p.503-506
Malikova G.Yu., Azimova M.T. “Influence of hypoglycemic collection on glucose catabolism in experimental hyperglycemia” Pharmaceutical science and practice: problems, achievements, prospects for development” Kharkiv 2016 24-25 birch 2016 C 287-289
Jamshid Mohammadi. Evolution of hypoglycemic effect of Morus alba in an animal model /Jamshid Mohammadi, Prakash R.Naik//Indian J.of Pharmacology-February 2008.Vol.40.P.15-18
G.Yu. Malikova, A.A. Zhuraeva, N.T. Farmanova, A.N. Maksudova., Sh.I. Azizov. “Hyperglycemia of sharaitide hypoglycemic yigma kuruk extractining glucose catabolismmiga tasirini ўrganish”// Uzbekiston Pharmaceutical Khabarnomasi. Ilmiy amaliy pharmaceutics journal - T.-2014. -№3 –S.48-52
V.S. Kamyshnikova Methods of clinical laboratory research. (3rd edition, revised and enlarged). - M. -2009.-С540-543
Saethaweesuk S. The study of hipoglikemic effect of Morus alba L. Leave extract and histology of the pankreatik islet cells in diabetic and normal rats / saenthweesuk S., thuhhia A, Rabintossaporn P/, Ingkaninan K/ [et al.] / / Thammas medical J.Vol. 9.No.2. April-June 2009. P.148-155.
Burgess S.C. [and etc.]. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. // The Journal of biological chemistry. 2004. No. 47 (279). C. 48941–9.
A.A.Abidov, H.U.Aliev, U.M.Azizov, D.S.Pulatova.” Study of the hypoglycemic effect of herbal preparations based on a mixture of dry extracts”//Pharmaceutical Journal. –T.-2012.-.№2–S.79-81
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