POLYCYSTIC OVARY SYNDROME (PCOS): MODERN UNDERSTANDING AND CLINICAL PRACTICE IN UZBEKISTAN (2020–2025)
DOI:
https://doi.org/10.37547/Keywords:
polycystic ovary syndrome, hyperandrogenism, insulin resistance, Uzbekistan, infertility, metformin, GLP-1.Abstract
Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrine and metabolic disorder, affecting 4% to 20% of reproductive-aged women globally. The condition is characterized by a complex interplay of reproductive dysfunctions, such as anovulation and hyperandrogenism, alongside severe metabolic risks, including insulin resistance and type 2 diabetes. Despite decades of research, the primary etiology of PCOS remains a subject of debate, focusing on the interaction between genetic predisposition and environmental factors. This thesis analyzes contemporary evidence on pathogenesis from 2020–2025, including the roles of neuroendocrine regulation and epigenetic mechanisms. Special attention is given to the regional specificities of Uzbekistan, where the high social value placed on childbearing makes PCOS-related infertility a significant factor in psychological and social maladjustment. Innovative therapeutic methods, such as GLP-1 receptor agonists and inositols, are discussed, alongside the necessity of implementing national screening programs.
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References
1.Teede HJ, et al. Recommendations from the 2023 International Evidence-based Guideline for PCOS. Fertil Steril. 2023;120(4).
2.Dong J, et al. Polycystic ovary syndrome: pathophysiology and treatment trends. BMJ Medicine. 2023;2(1).
3.Usanova MD, et al. Clinical features of hypertension and subclinical hypothyroidism in pregnancy in Uzbekistan. Acta Biomedica. 2023.
4.Statistics of the Republican Center of Endocrinology of Uzbekistan, 2019–2023.
5.Wang J, et al. Evolving global trends in PCOS burden and risk factors. Lancet EClinicalMedicine. 2025.
6.Rasquin LI, et al. Polycystic Ovarian Syndrome. StatPearls. 2024.
