Diabetic polyneuropathy (DPN) is a disease characterized by the presence of symptoms and signs of dysfunction of peripheral nerves in patients with diabetes mellitus (DM), with the exclusion of other causes of polyneuropathy. DPN is the most common complication of diabetes and, depending on the severity of symptoms, can significantly reduce the quality of life of patients. The incidence of DPN varies widely, which is associated with different methods of diagnosing the disease. On average, DPN develops 5 years after the onset of type 1 diabetes (T1DM) and is observed in 10-15% of cases in newly diagnosed patients with type 2 diabetes (T2DM).DPN occurs in at least 20% of patients with T1DM 20 years after diabetes onset and in approximately 50% of patients with T2DM 10 years after diagnosis.

Maffi P, Secchi A. The Burden of Diabetes: Emerging Data. Dev Ophthalmol. 2017;60(6):1-5. https://doi.org/10.1159/000459641

Liu X, Xu Y, An M, Zeng Q. The risk factors for diabetic peripheral neuropathy: a meta-analysis. PLoS One. 2019;14(2):e0212574.

Дедов И.И., Шестакова М.В., Викулова О.К. Государственный регистр сахарного диабета в Российской Федерации: статус 2014 г. и перспективы развития. Сахарный диабет. 2015;18(3):5-23. https://doi.org/10.14341/DM201535-22

Callaghan BC, Cheng HT, et al. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol. 2012;11(6):521-534. https://doi.org/10.1016/S1474-4422(12)70065-0

Zubair M, Ahmad J. Role of growth factors and cytokines in diabetic foot ulcer healing: A detailed review. Rev Endocr Metab Disord. 2019;20(2):207-217. https://doi.org/10.1007/s11154-019-09492-1

Kartika RW, Alwi I, Suyatna FD, et al. The role of VEGF, PDGF and IL-6 on diabetic foot ulcer after Platelet Rich Fibrin + hyaluronic therapy. Heliyon. 2021;7(9):e07934. https://doi.org/10.1016/j.heliyon.2021.e07934

Várkonyi T, Körei A, Putz Z, et al. Advances in the management of diabetic neuropathy. Minerva Med. 2017;108(5):419-437.

Thakur V, Sadanandan J, Chattopadhyay M. High-Mobility Group Box 1 Protein Signaling in Painful Diabetic Neuropathy. Int J Mol Sci. 2020;21(3):881. https://doi.org/10.3390/ijms21030881

Давыдов О.С., Яхно Н.Н., Кукушкин М.Л. и др. Невропатическая боль. Клинические рекомендации по диагностике и лечению. РОИБ. М. 2018;1-88. https://doi.org/10.25731/RASP.2018.04.025

Храмилин В.Н., Демидова И.Ю. Особенности диагностики и лечения диабетической полинейропатии у пожилых пациентов. Эффективная фармакотерапия. 2020;16(12):42-54. https://doi.org/10.33978/2307-3586-2020-16-12-42-54

Attal N. Pharmacological treatments of neuropathic pain: The latest recommendations. Rev Neurol (Paris). 2019;175(1-2):46-50.