A CASE OF CUTANEOUS SARCOIDOSIS.

Authors

  • A.B.Raxmatov "Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology," Ministry of Health of the Republic of Uzbekistan
  • X.I.Nasimov "Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology," Ministry of Health of the Republic of Uzbekistan
  • B.R.Madreymov "Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology," Ministry of Health of the Republic of Uzbekistan
  • S.F.Shoximardonova "Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology," Ministry of Health of the Republic of Uzbekistan

DOI:

https://doi.org/10.37547/

Keywords:

skin sarcoidosis, clinical features, diagnostics, treatment.

Abstract

Cutaneous sarcoidosis is a specific manifestation of a systemic granulomatous disease of unknown etiology, occurring in approximately one-quarter of patients with sarcoidosis and characterized by exceptional clinical polymorphism. This article reviews current data on the epidemiology, etiopathogenesis, classification, histopathology, differential diagnosis, and treatment of cutaneous sarcoidosis, and presents an original clinical case — a papulo-plaque form of the disease in a female patient with widespread, symmetric lesions of the face, trunk, and limbs requiring inpatient treatment; the diagnosis was histologically confirmed by the detection of non-caseating epithelioid-cell granulomas in a skin biopsy. The effectiveness of stepwise therapy, including systemic glucocorticosteroids, antihistamines, topical agents, and physiotherapy, is demonstrated, and the need to exclude systemic involvement in newly diagnosed cutaneous sarcoidosis is emphasized.

Downloads

Download data is not yet available.

References

1. Ahmed I, Harshad SR. Subcutaneous sarcoidosis: is it a specific subset of cutaneous sarcoidosis frequently associated with systemic disease? J Am Acad Dermatol. 2006;54:55–60.

2. Baughman RP, Judson MA, Lower EE, et al. Infliximab for chronic cutaneous sarcoidosis: a subset analysis from a double-blind randomized clinical trial. Sarcoidosis Vasc Diffuse Lung Dis. 2016;32:289–295.

3. Baughman RP, Lower EE. A clinical approach to the use of methotrexate for sarcoidosis. Thorax. 1999;54:742–746.

4. Crouser ED, Maier LA, Wilson KC, et al. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020;201:e26.

5. Drake WP, Oswald-Richter K, Richmond BW, et al. Oral Antimycobacterial Therapy in Chronic Cutaneous Sarcoidosis: A Randomized, Single-Masked, Placebo-Controlled Study. JAMA Dermatol. 2013;149(9):1040–1049.

6. Drake WP, Pei Z, Pride DT, Collins RD, Cover TL, Blaser MJ. Molecular analysis of sarcoidosis tissues for Mycobacterium species DNA. Emerg Infect Dis. 2002;8(11):1334–1341.

7. Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM. The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review. J Am Acad Dermatol. 2013;69(4):609–615.

8. Ishak R, Kurban M, Kibbi AG, Abbas O. Cutaneous sarcoidosis: clinicopathologic study of 76 patients from Lebanon. Int J Dermatol. 2015;54:33–41.

9. James DG. The sarcoidosis movement and its personalities. J Med Biogr. 1995;3:148–160.

10. Katta R. Cutaneous sarcoidosis: a dermatologic masquerader. Am Fam Physician. 2002;65:1581–1584.

11. Koneti J, Cherukuri S, Gadde S, Kalluru R, Chikatimalla R, Dasaradhan T. Sarcoidosis and Its Dermatological Manifestations: A Narrative Review. Cureus. 2022;14(8):e28053.

12. Marcoval J, Mañá J, Rubio M. Specific cutaneous lesions in patients with systemic sarcoidosis: relationship to severity and chronicity of disease. Clin Exp Dermatol. 2011;36:739–744.

13. Nunes H, Bouvry D, Soler P, Valeyre D. Sarcoidosis. Orphanet J Rare Dis. 2007;2:46.

14. Prystowsky S, Sanchez M. Cutaneous manifestations of sarcoidosis. UpToDate. Literature review current through Jun 2026.

15. Roos S, Raulin C, Ockenfels HM, Karsai S. Successful treatment of cutaneous sarcoidosis lesions with the flashlamp pumped pulsed dye laser: a case report. Dermatol Surg. 2009;35(7):1139–1140.

16. Rybicki BA, Major M, Popovich J Jr, Maliarik MJ, Iannuzzi MC. Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol. 1997;145:234–241.

17. Sève P, Pacheco Y, Durupt F, et al. Sarcoidosis: a clinical overview from symptoms to diagnosis. Cells. 2021;10:766.

18. Spiteri MA, Matthey F, Gordon T, Carstairs LS, James DG. Lupus pernio: a clinico-radiological study of thirty-five cases. Br J Dermatol. 1985;112:315–322.

19. Tchernev G, Patterson JW, Nenoff P, Horn LC. Sarcoidosis of the skin — a dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition. J Eur Acad Dermatol Venereol. 2010;24:125–137.

20. Zic JA, Horowitz DH, Arzubiaga C, King LE Jr. Treatment of cutaneous sarcoidosis with chloroquine. Review of the literature. Arch Dermatol. 1991;127:1034–1040.

Downloads

Published

2026-08-12

How to Cite

A CASE OF CUTANEOUS SARCOIDOSIS. (2026). International Bulletin of Medical Sciences and Clinical Research, 6(8), 15-24. https://doi.org/10.37547/

Similar Articles

1-10 of 391

You may also start an advanced similarity search for this article.