GLIKOLIZ–LAKTAT–pH. NEYTROFIL IMMUNOMETABOLIZMINING “SWITCH” NUQTALARI
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Abstract
So‘nggi o‘n yillikda immunometabolizm sohasida erishilgan yutuqlar immun hujayralarining funktsional holati ularning metabolitik dasturlari bilan chambarchas bog‘liq ekanligini ko‘rsatdi. Ushbu sharh maqolada neytrofil immun hujayralarining glikoliz–laktat–pH o‘qi orqali boshqariladigan “switch” (o‘tish) nuqtalari tahlil qilingan. Neytrofillar mitoxondriyalari kam bo‘lgan va asosiy energiya ishlab chiqarish yo‘li glikolizga bog‘liq bo‘lgan immun hujayralar hisoblanadi . Ularning faollashuvi glikolitik fluxning keskin oshishi bilan kechadi, bu esa pirovard mahsulot sifatida laktatning to‘planishiga olib keladi. Laktat nafaqat metabolitik chiqindi, balki hujayra ichi va tashqi muhitda signal molekulasi sifatida ham xizmat qiladi . Laktatning to‘planishi mahalliy pH darajasining pasayishiga (asidoz) sabab bo‘ladi, bu esa o‘z navbatida neytrofillarning funktsional faolligiga, xususan, neytrofil hujayra tashqi tutoqlari (NET) hosil qilish qobiliyatiga ta’sir ko‘rsatadi . Tadqiqotlar shuni ko‘rsatadiki, laktat va pH o‘zgarishlari neytrofillarning yallig‘lanish joyidagi faolligini modulyatsiya qiluvchi muhim omillardir .
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