IMMUNOHISTOCHEMICAL ANALYSIS OF AGE-RELATED FACTORS IN POST-TRAUMATIC FORMS OF RHINOSINUS POLYPS
DOI:
https://doi.org/10.37547/Keywords:
rhinosinus polyps, post-traumatic, immunohistochemistry, age-related changes, morphology.Abstract
This study investigates the age-related immunohistochemical characteristics of post-traumatic rhinosinus polyps. Morphological and immunohistochemical analyses of polyp tissues were performed, including the assessment of T- and B-lymphocytes, macrophages, and cytokine expression, with comparisons across different age groups. The results demonstrate that age significantly influences the immunological profile of polyp tissue, with notable differences in inflammatory cell activity and cytokine expression observed in younger patients. This research provides insights into the pathogenesis of post-traumatic rhinosinus polyps and the mechanisms of age-dependent immune responses, offering valuable data for the development of individualized clinical management strategies.
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References
1. Vaitkus J. et al. Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers. Medicina (Kaunas). 2021;57(3):282. 1–8.
2. Schleimer R. P. et al. Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis. Annu. Rev. Pathol. 2017;12: 331–350.
3. Kato A. Immunopathology of chronic rhinosinusitis. Clin. Exp. Allergy 2015;45(2):325–337.
4. Vaitkus J. et al. Chronic Rhinosinusitis with Nasal Polyps… IL 2, IL 4, IL 5, IL 22 in Age Groups. Medicina. 2021;57(3): 3-6.
5. Gelardi M. et al. Nasal cytology and histology in CRSwNP: Two sides of the coin. Front. Med. 2023;10:1143351.
6. Farokhi S. Chronic Rhinosinusitis with Nasal Polyps: Window of Immune Mechanisms and Targeted Therapies. MDPI 2025;5(3):26.
7. Age-related altered IL 6 trans signalling and S100 protein expression in nasal polyps patients, PubMed. 1-7.
8. Xu J. et al. Role of Interleukin-10 on Nasal Polypogenesis in Patients with CRSwNP. PLoS ONE 2016;11(9):e0161013.
9. Fokkens W.J., Lund V.J., Hopkins C. et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020). Rhinology. 2020;58(Suppl S29):1–464.
10. Van Zele T., Claeys S., Gevaert P. et al. Cytokines in Chronic Rhinosinusitis. Am. J. Respir. Crit. Care Med. 2014;190(11):1253–1262.
11. Bernstein J.M., Baraniuk J.N., Bachert C. Allergic Rhinitis and Nasal Polyps: Histopathological Study. PubMed. 2013;45(2):101–110.
12. Smith K., Patel Z., Jones T. Quality of Life of Patients with Chronic Polypous Rhinosinusitis. J. Otolaryngol. Head Neck Surg. 2015;44(1):1–8.
13. Ivanov A., Petrov S. Masks of Polypous Rhinosinusitis. Science and Innovations in Medicine. 2017;13(4):45–52.
14. Karpov A., Smirnova T. Polypoid Rhinosinusitis: Modern Approach to Treatment. Consilium Medicum. 2018;10(1):1–7..
