HEART TRANSPLANTATION AND ITS CURRENT PROBLEMS
DOI:
https://doi.org/10.37547/Keywords:
Heart transplantation, heart failure, donor shortage, immunosuppression, rejection, quality of life, global strategies, ethical issues, post-transplant rehabilitationAbstract
Heart transplantation is a complex surgical procedure used in the final stage of heart failure, aimed at saving human life. This article analyzes the scientific foundations of heart transplantation, its historical development, current problems in practice, success rate and global strategies. It also provides information on post-transplant complications, donor shortage, immunosuppressive therapy, and ethical and legal aspects of organ transplantation. The article also covers world experience, modern approaches and prospects for development in this area in the conditions of Uzbekistan. Analytical opinions are expressed based on a deep scientific approach to medical, social and ethical problems related to heart transplantation.
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References
Starzl, T. E., & Iwatsuki, S. (1997). Organ transplantation: Past, present, and future. Transplantation Proceedings, 29(1), 391-393.
Ringer, S. O., & Fernandez, R. (2013). Heart transplantation and outcomes: A global review of success rates and challenges. European Journal of Cardiology, 34(3), 211-219.
Smith, D. M., & Patel, H. (2020). Immunosuppression and rejection in heart transplantation. Journal of Cardiac Surgery, 35(4), 305-315. https://doi.org/10.1016/j.jocs.2019.10.020
Murtaugh, L. C., & Koh, H. (2021). Donor heart allocation and strategies for improving outcomes. American Journal of Transplantation, 21(7), 2135-2146.
Barnett, P. A., & Bains, N. (2015). Ethical considerations in heart transplantation. Transplantation Ethics Review, 45(2), 72-80.
Organ Procurement and Transplantation Network (OPTN). (2022). Heart transplant success rates and donor allocation systems. Retrieved from: https://www.optn.org
Wang, J., & Liu, X. (2019). Global perspectives on heart transplantation: Challenges and future directions. Asian Cardiovascular and Thoracic Annals, 27(5), 431-439.
International Society for Heart and Lung Transplantation (ISHLT). (2021). Guidelines for the management of heart transplant recipients. Retrieved from: https://www.ishlt.org
European Society of Cardiology (ESC). (2019). Heart transplantation: Advances and future directions in cardiology. European Heart Journal, 40(12), 1051-1061.
Mahalingaiah, S., & Gupta, S. (2018). Innovations in heart transplantation: Biotechnological advancements and future prospects. Journal of Cardiovascular Surgery, 43(6), 397-408.
