FARMATSEVTIKA SANOATIDA KLINIK TADQIQOTLAR VA ULARNING AHAMIYATI
DOI:
https://doi.org/10.37547/Keywords:
klinik tadqiqotlar, dori sinovlari, klinik bosqichlar (I–IV), xavfsizlik, samaradorlik, randomizatsiya, ikki tomonlama ko'r usul, farmakokinetika, Good Clinical Practice.Abstract
Ushbu maqolada farmatsevtika sanoatida klinik tadqiqotlarning tutgan o'rni va ularning yangi dori vositalarini yaratish jarayonidagi ahamiyati ko'rib chiqiladi. Maqolada klinik sinovlarning to'rt bosqichi, ularda qo'llaniladigan asosiy uslublar — randomizatsiya, plasebo nazorat, ikki tomonlama ko'r (double-blind) usul — hamda xalqaro talablar, jumladan Good Clinical Practice, FDA va EMA tomonidan qo'yiladigan mezonlar tahlil qilinadi. Xulosada klinik tadqiqotlarning dori vositalari xavfsizligi va samaradorligini ta'minlashdagi hal qiluvchi o'rni asoslab beriladi.
Downloads
References
1. Aronson J.K. Clinical Pharmacology. Oxford University Press, 2020.
2. Chow S.C., Liu J.P. Design and Analysis of Clinical Trials. Wiley, 2018.
3. Friedman L.M., Furberg C.D., DeMets D.L. Fundamentals of Clinical Trials. Springer, 2015.
4. Piantadosi S. Clinical Trials: A Methodologic Perspective. Wiley, 2017.
5. Fletcher R.H., Fletcher S.W., Fletcher G.S. Clinical Epidemiology. Lippincott Williams & Wilkins, 2017.
6. International Council for Harmonisation (ICH). E6 Good Clinical Practice Guidelines, 2016.
7. World Health Organization. Handbook for Good Clinical Research Practice. Geneva, 2019.
8. Food and Drug Administration. Drug Development and Approval Process. USA, 2023.
9. European Medicines Agency (EMA). Guideline on Clinical Trials Regulation. 2022.
10. Julious S.A. Sample Sizes for Clinical Trials. CRC Press, 2010.
11. O'zbekiston Respublikasi Sog'liqni saqlash vazirligi. Farmakologik vositalar va dori vositalarining klinik tadqiqotlarini o'tkazish tartibi to'g'risidagi nizom, 2026
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license:
- Share: Copy and redistribute the material in any medium or format
- Adapt: Remix, transform, and build upon the material for any purpose, including commercially
Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made.
License URL: https://creativecommons.org/licenses/by/4.0/
Authors retain copyright of their work while granting the journal first publication rights.
