CLINICAL AND IMMUNOLOGICAL PREDICTORS OF THE SEVERE CURRENT ACUTE OF ACUTE ADHESIVE INJECT INTESTINAL CONTRACTION
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Abstract
Acute adhesive small intestinal obstruction (AICOB) remains one of the most complex forms of emergency abdominal pathology, characterized by a high frequency of complications, relapses, and mortality. The purpose of the study was to assess the prognostic significance of clinical and immunological indicators as factors of stratification of disease severity and the risk of adverse outcomes. 115 patients with the established diagnosis of PCOS were examined, who were divided into groups depending on the clinical form and severity of the condition. It was established that a pronounced decrease in CD4+ and HLA-DR+, a disbalance of CD4/CD8, an increase in the levels of IL-6, TNF-α, and circulating immune complexes (CIC) are reliably associated with a complicated course of the disease and the need for emergency surgical intervention. ROC analysis showed high diagnostic accuracy of IL-6 and HLA-DR+ (AUC > 0.90). The obtained data confirm the possibility of using immunological indicators as reliable prognostic markers for OCTK.
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