Age-related immunohistochemical characteristics of blood vessels in the lower leg and foot region in diabetic angiopathies in post-COVID syndrome

Authors

  • Zarif Narbayev Andijan State Medical Institute Department of Otorhinolaryngology.
  • Zafar Narbaev Kamilovich Andijan State Medical Institute Department of Otorhinolaryngology.
  • Kamil Pozilovich Narbaev Andijan State Medical Institute Department of Otorhinolaryngology.

DOI:

https://doi.org/10.5281/zenodo.23594237

Keywords:

post-COVID syndrome, diabetes mellitus, diabetic angiopathy, lower leg blood vessels, hand blood vessels, age-related changes, immunohistochemistry.

Abstract

This article analyzes pathological changes in the blood vessels of the lower leg and foot in patients with diabetes mellitus in connection with post-COVID syndrome, their age-related characteristics, and the possibilities of immunohistochemical examination. Chronic hyperglycemia, endothelial dysfunction, oxidative stress, inflammatory processes, and microcirculatory disorders characteristic of diabetes mellitus play an important role in the formation of peripheral angiopathies.

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References

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Brownlee M. “The Pathobiology of Diabetic Complications: A Unifying Mechanism.” Diabetes, 2005; 54(6): 1615–1625. DOI: https://doi.org/10.2337/diabetes.54.6.1615.

Temirov S. N., Magrupov B. A., Tursunov B. Z. “Pathomorphology of Arteries, Mineral Metabolism and Vitamin D in Critical Ischemia of the Lower Limbs in Patients with Diabetes Mellitus.” The Bulletin of Emergency Medicine, 2022; 14(6). DOI: https://doi.org/10.54185/tbem/vol14_iss6/a8.

Aliyeva A. V. “The Risk of Thrombotic Complications in Patients with Post-COVID Syndrome Is High Even with Normal Coagulogram Values.” Journal of the Endocrine Society, 2024; 8(Supplement 1): bvae163.968. DOI: https://doi.org/10.1210/jendso/bvae163.968.

Ramos-Vara J. A. “Technical Aspects of Immunohistochemistry.” Veterinary Pathology, 2005; 42(4): 405–426. DOI: https://doi.org/10.1354/vp.42-4-405.

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Published

2026-10-23

Issue

Vol. 6 No. 10 (2026): International Bulletin of Medical Sciences and Clinical Research

Section

Articles

License

Copyright (c) 2026 Zarif Narbayev, Zafar Narbaev Kamilovich, Kamil Pozilovich Narbaev

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How to Cite

Narbayev, Z., Narbaev Kamilovich, Z., & Narbaev, K. P. (2026). Age-related immunohistochemical characteristics of blood vessels in the lower leg and foot region in diabetic angiopathies in post-COVID syndrome. International Bulletin of Medical Sciences and Clinical Research, 6(10), 61-65. https://doi.org/10.5281/zenodo.23594237