THE SIGNIFICANCE OF CLINICAL AND INSTRUMENTAL INDICATORS IN PREDICTING MENSTRUAL DISORDERS IN ADOLESCENT GIRLS

Abstract

Background. Adolescent menstrual abnormalities may resolve with maturation or persist into adulthood. Distinguishing these trajectories requires evidence beyond a single abnormal test. Objective. To evaluate the prognostic significance of clinical, hormonal and ultrasound indicators in adolescent girls with menstrual disorders. Materials and methods. A targeted narrative review integrated longitudinal cohort studies, international clinical recommendations and prediction-methodology guidance. Associations, individual prediction and diagnostic criteria were assessed separately. No pooled estimates were calculated. Results. Persistent cycle irregularity provides clinically relevant longitudinal information. Hyperandrogenism and anthropometric trajectories refine interpretation, but their usefulness depends on the population and outcome. Anti-Müllerian hormone and ovarian morphology have not demonstrated sufficient incremental value to justify routine adolescent prognostic screening. Available evidence predominantly concerns oligomenorrhoea and polycystic ovary syndrome; it cannot be generalised to every menstrual disorder. Cohort overlap, attrition and heterogeneous outco me definitions limit certainty.