International Bulletin of Medical Sciences and Clinical Research
International Bulletin of Medical Sciences and Clinical Research (ISSN-2750-3399) is an open access international peer reviewed german journal. IBMSCR publishes research monthly frequency basis. we explore your research worldwide by international Database indexings. we provide all articles crossref metadata link, google scholar, microsoft academic, Metadata Indexing and much more worldwide international indexings. Administer With Case Save Time With Automation 5000 Online Courses
NON-ALCOHOLIC FATTY LIVER DISEASES AS A LEADING CAUSE TO LIVER CIRRHOSIS
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disorder globally, closely associated with obesity, insulin resistance, and metabolic syndrome. This review aims to analyze NAFLD as a leading cause of liver cirrhosis by summarizing current evidence on its epidemiology, risk factors, pathogenesis, and clinical significance. Epidemiological studies indicate that approximately 24–30% of adults worldwide are affected by NAFLD, with prevalence rising even among adolescents and young adults. Key mechanisms driving disease progression include hepatic fat accumulation, insulin resistance, oxidative stress, and chronic inflammation. NAFLD can progress from simple steatosis to non-alcoholic steatohepatitis (NASH), advanced fibrosis, and ultimately cirrhosis, leading to significant morbidity and mortality. Early recognition, lifestyle modification, and targeted interventions are essential to reduce the clinical burden and prevent long-term hepatic complications.
Non-alcoholic fatty liver disease, NAFLD, NASH, liver cirrhosis, metabolic syndrome, epidemiology, pathogenesis
Copyright (c) 2026 https://creativecommons.org/licenses/by/4.0
BASING AND FORECASTING THE PRIORITIES FOR THE INTRODUCTION OF INNOVATIVE MEDICAL SERVICES IN THE REGION
In this article, the results of the forecast for the development of the medical services market in the region for the period of 2022-2026 are presented. According to it, factors such as the number of private clinics and the number of employees of medical institutions in the development of the medical services market were made using the regression analysis method.
Model, quality medical service,private clinics,the number of medical personnel,private sector, health services,correlational analysis,real income, service price,population income, MARE indicator, Durbin-Watson index, Regression analysis.
STUDYING THE EFFECT OF THE BIOLOGICALLY ACTIVE SUPPLEMENT “ADAPTOFIT” ON PHYSICAL ENDURANCE
Nowadays, no one is immune to stress and fatigue. These factors have a negative impact on human health. In such cases, adaptogens are used. Adaptogens are drugs that adapt the body to various adverse conditions, increase physical and mental endurance, reduce fatigue, and normalize sleep. In recent decades, medicinal plants such as eleutherococcus, rhodiola rosea, astragalus, ginseng, and ginger have been widely used in practical medicine. [1, 2] Preparations made from these plants are widely used to increase physical and mental performance in athletes and people engaged in mental labor, as well as in the complex treatment and medical rehabilitation of weakened patients. [3] Adaptogens regulate the production and consumption of energy in the cells of muscles, liver, kidneys, brain, and other organs. They have an antioxidant effect and reduce the damage caused by free radicals. They also prevent hypoxia, which almost always accompanies intensive physical work, and with the participation of these mechanisms, microcirculation in the vessels of the brain and working muscles improves by improving the rheological properties of the blood.
physical endurance, adaptogen, white mice, tincture, Adaptofit
CHANGES IN LIVER STRUCTURE IN OFFSPRING UNDER THE INFLUENCE OF PRENATAL STRESS
Prenatal stress is a psycho-emotional and physiological strain occurring in the maternal organism during pregnancy, significantly affects the development of embryonic organs. This article analyzes morphological and functional changes in the liver tissue of offspring under the influence of prenatal stress. Scientific studies have revealed dystrophic changes in hepatocytes, compaction of sinusoids, impaired microcirculation, and increased markers of oxidative stress. These alterations may lead to disrupted liver development and metabolic dysfunction. Furthermore, elevated levels of glucocorticoids in the maternal organism are shown to program fetal liver development, which may later result in fibrosis, steatosis, and various liver dysfunctions.
Cells, prenatal stress, offspring, liver, hepatocytes, morphology, microcirculation, dystrophic changes, oxidative stress, apoptosis, hypothalamic-pituitary-adrenal (HPA) system, embryo.
СОВЕРШЕНСТВОВАНИЕ ТАКТИКИ ПОДГОТОВКИ К ДЕНТАЛЬНОЙ ИМПЛАНТАЦИИ НА ОСНОВЕ СТАНДАРТИЗИРОВАННОГО РИСК-ОРИЕНТИРОВАННОГО ПРОТОКОЛА
Разработать и методически обосновать стандартизированную риск-ориентированную тактику подготовки пациентов к дентальной имплантации, объединяющую оценку факторов риска, клиническую стабилизацию, выбор лучевой диагностики, цифровое протезно-ориентированное планирование, критерии готовности к хирургическому этапу и последующее supportive peri-implant care.
дентальная имплантация; подготовка к имплантации; периимплантный мукозит; периимплантит; риск-стратификация; supportive peri-implant care; КЛКТ; цифровое планирование; клинический протокол; реестр пациентов.
ENDOFILLING YORDAMIDA APIKAL PERIODONTITDA ENDODONTIK OBTURATSIYA: DALILLARGA ASOSLANGAN TAHLIL VA KLINIK BAHOLASH MODELI
Ushbu maqolaning maqsadi apikal periodontitda Endofillingni qo‘llashning dalillarga asoslangan klinik mantiqini, material tanlash mezonlarini va natijani baholashning amaliy modelini aniqlashdan iborat.
apikal periodontit, Endofilling, endodontik obturatsiya, siz, PAI, CBCT-PAI, operatsiyadan keyingi og‘riq, ekstruziya, dalillarga asoslangan stomatologiya.
КЛИНИЧЕСКИЕ ПОСЛЕДСТВИЯ ПРЕДОПЕРАЦИОННОЙ ТРЕВОЖНОСТИ ПЕРЕД АМБУЛАТОРНОЙ ЭКСТРАКЦИЕЙ ЗУБА: СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ПАЦИЕНТОВ С ПСИХИЧЕСКИМИ РАССТРОЙСТВАМИ И БЕЗ НИХ
Статья посвящена оценке предоперационного психоэмоционального состояния взрослых пациентов перед амбулаторной экстракцией зуба с анализом его связи с гемодинамическими реакциями, болью и стоматологическим статусом, а также выявлением предикторов высокой тревожности. Материалы и методы включают проспективное исследование 100 пациентов. Основная группа — 50 пациентов с психическими расстройствами, контроль — 50 психически здоровых. Оценка проводилась в точках T0–T6 с использованием шкалы Спилбергера–Ханина, ВАШ, показателей гемодинамики и индексов PI, GI, CPITN, DMFT. Применены корреляционный анализ и логистическая регрессия.
предоперационная тревожность; экстракция зуба; психические расстройства; гемодинамическая реакция; боль; стоматологический статус; стратификация риска.
RETENSIYALANGAN PASTKI UCHINCHI MOLYARLARNI OLIB TASHLASHDA ERTA VA KECHKI ASORATLAR PROFILAKTIKASI: MAGISTRLIK DISSERTATSIYASI MATERIALLARI ASOSIDAGI ANALITIK SHARH
Ushbu maqolada retensiyalangan pastki uchinchi molyarlarni olib tashlashda yuzaga keladigan erta va kechki asoratlar, ularning xavf omillari hamda profilaktika choralarini magistrlik dissertatsiyasining nazariy qismida jamlangan manbalar asosida tizimlashtirish ko‘zda tutiladi.
retensiyalangan pastki uchinchi molyar, alveolit, pastki alveolyar nerv, KNKT, koronektomiya, jarrohlik stomatologiyasi, profilaktika.
НЕИНВАЗИВНАЯ ДИАГНОСТИЧЕСКАЯ ПАНЕЛЬ НА ОСНОВЕ СЛЮННЫХ БИОМАРКЕРОВ ПРИ БРОНХИАЛЬНОЙ АСТМЕ И ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЁГКИХ
Cравнительно оценить иммунобиохимические и физико-химические показатели слюны при бронхиальной астме и хронической обструктивной болезни лёгких (ХОБЛ), а также определить диагностическую эффективность интегральной панели IL-6+IL-8+ECP+pH.
слюнные биомаркеры; бронхиальная астма; ХОБЛ; эозинофильный катионный белок; IL-6; IL-8; pH; неинвазивная диагностика
СРАВНИТЕЛЬНАЯ КЛИНИЧЕСКАЯ ОЦЕНКА КРЕМООБРАЗНЫХ АДГЕЗИВНЫХ СРЕДСТВ COREGA И PROTEFIX ПРИ ФИКСАЦИИ ПОЛНЫХ СЪЁМНЫХ ПЛАСТИНОЧНЫХ ПРОТЕЗОВ
Статья посвящена сравнительной клинической оценке кремообразных адгезивных средств Corega и Protefix у пациентов с полными съёмными пластиночными протезами в течение 30-дневного периода наблюдения.
полная адентия, полные съёмные пластиночные протезы, адгезивные средства, Corega, Protefix, фиксация протеза, адаптация.
TANANGIZ SIGNAL BERMOQDA:KASALLIK ALOMATLARINI BILASIZMI?
Anemiya qanday davolanishini, albatta, shifokor tayinlaydi. Lekin bazan shunday vaziyatlar ham uchraydiki, shifokor tavsiya qilgan davolash usullaridan so’ng bemorning umumiy ahvoli vaqtincha yaxshilangach, xotirjamlikka berilgan bemorning o’zi davolashni muddatidan avval to’xtatib qo’yadi. Keyingi safar axvoli yomonlashganda esa, endi mutaxassisga murojaat qilmay, o’zi mustaqil davolanishga urunib ko’radi. Yuqoridagi vaziyatlar tez-tez uchrab turushini, shuningdek, bemorlarga ularning kasalligi, uni davolash va profilaktikasi haqida kengroq tushuncha berish zarurligi shifokorlar o’rtasida umumtan olingan ushbu maqola ham anemiyani davolash muammolarining eng asosiy jihatlariga to’xtalib o’tish foydadan holi emasligi anglashiladi. Qaryib 30 yil avval L.I. Idelson tomonidan shakllantirilgan anemiyani davolash tamoyillari bugungi kunda ham o’z dolzarbligini yo’qotmagan: Anemiya temir tanqisligini tarkibida temir moddasi mavjud preparatlarsiz faqat parxez asosida bartaraf qilish mumkin emas. Anemiya asosan ichga qabul qilinadigan temir saqlovchi preparatlar bilan davolanadi. Anemiyani davolash gemoglobin miqdori normal darajaga yetgandan keyin to’xtatib qo’yilmaydi. Anemiyada gemotransfuziya faqat hayot ko’rsatkichlari bo’yicha o’tkaziladi.
Anemiya, TTA, gemolitik animiya, irsiy enziopatiya, gemoglobin, eritrositlar, pernitsioz, B12, foliy tanqisligi animiyasi, aplastik animiya, gemoliz, irsiy ferositoz(Minkovskiy-Shoffar kasalligi), talassemiya, oroqsimon hujayra animiyasi, autoimmune gemolitik anemiya(AIGA), paroksizmal tungi gemoglobinuriya.
SYSTEMATIC REVIEW OF HEPATIC SINUSOIDAL DILATATION IN RODENT FEEDING STUDIES OF GLYPHOSATE-TOLERANT GM CROPS AND ITS TRANSLATIONAL IMPLICATIONS FOR HUMAN LIVER MICROVASCULAR HEALTH
Hepatic sinusoidal dilatation (HSD) is a histopathological alteration characterized by the widening of hepatic sinusoids and is associated with a range of physiological and pathological conditions, including toxic injury and vascular disturbances. This systematic review evaluates the occurrence of HSD in rodent feeding studies involving glyphosate-tolerant genetically modified (GM) crops and examines its translational relevance for human liver microvascular health. A comprehensive analysis of experimental and regulatory studies reveals that while sinusoidal dilatation has been reported in some rodent models, its frequency, severity, and reproducibility remain inconsistent across studies; in most cases, HSD appears as a mild and isolated finding without clear dose–response relationships or accompanying biochemical evidence of hepatotoxicity, suggesting a predominantly adaptive or incidental nature.
hepatic sinusoidal dilatation; glyphosate-tolerant crops; genetically modified organisms; rodent feeding studies; liver microvascular health; translational toxicology; sinusoidal endothelial cells; food safety assessment; histopathology; oxidative stress.
ВОЗРАСТНАЯ ИММУНОГИСТОХИМИЧЕСКАЯ ХАРАКТЕРИСТИКА КРОВЕНОСНЫХ СОСУДОВ СТОП И ГОЛЕНОСТОПНЫХ СУСТАВОВ ПРИ ДИАБЕТИЧЕСКИХ АНГИОПАТИЯХ ПРИ ПОСТКОВИДНОМ СИНДРОМЕ
В работе представлена возрастная иммуногистохимическая характеристика кровеносных сосудов стоп и голеностопных суставов при диабетических ангиопатиях в условиях постковидного синдрома. Изучены морфофункциональные изменения сосудистой стенки у пациентов различных возрастных групп с сахарным диабетом, перенесших COVID-19. Особое внимание уделено экспрессии эндотелиальных маркеров, воспалительных и пролиферативных факторов, отражающих степень повреждения сосудов. Выявлены возрастные особенности ремоделирования сосудистой стенки, усугубляющиеся под влиянием постковидных изменений. Установлено, что сочетание диабетической ангиопатии и постковидного синдрома приводит к более выраженным нарушениям микроциркуляции, эндотелиальной дисфункции и прогрессированию сосудистых осложнений. Полученные результаты могут быть использованы для разработки новых подходов к диагностике и лечению сосудистых осложнений у пациентов с сахарным диабетом.
диабетическая ангиопатия, постковидный синдром, иммуногистохимия, кровеносные сосуды, эндотелий, микроциркуляция, голеностопный сустав, стопа, сахарный диабет, сосудистые изменения, возрастные особенности, эндотелиальная дисфункция.
INTERRELATIONSHIP BETWEEN MICRONUTRIENT STATUS AND GUT MICROBIOTA IN CHILDREN WITH COMMUNITY-ACQUIRED PNEUMONIA AND ITS IMPACT ON DISEASE SEVERITY
Community-acquired pneumonia (CAP) remains one of the leading causes of hospitalization and mortality in children worldwide. This review explores the complex bidirectional relationship between micronutrient status (particularly zinc, vitamin D, iron, and vitamin A) and gut microbiota composition in pediatric patients with CAP, and examines how this interplay influences disease severity. The gut-lung axis serves as the central mechanism through which microbial metabolites (especially short-chain fatty acids) and micronutrient-dependent immune pathways modulate pulmonary inflammation, epithelial barrier integrity, and host defense. Micronutrient deficiencies alter microbial diversity, reduce colonization resistance, and promote dysbiosis, while dysbiotic microbiota exacerbates nutrient malabsorption and systemic inflammation, creating a vicious cycle that worsens clinical outcomes such as prolonged hypoxia, elevated inflammatory markers, and increased complication rates. Understanding these interactions opens new avenues for integrated nutritional and microbiota-targeted interventions to reduce severity and improve prognosis in children with CAP. This paper synthesizes current evidence on the molecular and clinical dimensions of this relationship and highlights future directions for precision medicine approaches.
Community-acquired pneumonia, gut microbiota, micronutrient status, gut-lung axis, zinc deficiency, vitamin D, dysbiosis, disease severity, pediatric respiratory infections, short-chain fatty acids
ATTENTION DEFICIT SYMPTOMS AS A POST-COVID COGNITIVE CONSEQUENCE
COVID-19 has left a lot of people with impairment. One of the common problems people have is with attention deficits. This means they have trouble focusing and paying attention. We looked at how this happens what it looks like and how it affects people. We also looked at why it happens how it is diagnosed and how it affects the quality of life of COVID-19 patients. A lot of studies show that 20 to 30 percent of people who had COVID-19 have trouble with concentration get tired easily have memory problems and have trouble making decisions. This is true for people who only had mild or moderate COVID-19. The reasons for this are complicated. It involves inflammation in the brain not getting oxygen, damage to blood vessels and psychological factors. It is hard to diagnose because the symptoms can be similar to conditions. Also there are no tests, for it and some people may not even realize they have it. Attention deficits can really affect peoples lives. It can make it hard for them to do well in school or work. It can make everyday tasks difficult. It also affects their quality of life. So it is really important to catch it and do something about it. To manage attention deficits people can try to rehabilitate their function make lifestyle changes and get psychological support. It is also important to monitor patients and raise awareness about the issue. Attention deficits are a part of what happens to people after they have COVID-19. We need to do research and take action to prevent long-term cognitive problems. COVID-19 patients need help to deal with attention deficits and other cognitive issues.
Post-COVID cognitive impairment, attention deficit, neurocognitive dysfunction, neuropsychological testing, long COVID, executive function, risk factors
“CONSEQUENCES OF MISUSE OF ANTIBIOTICS AND ITS ROLE AS A GLOBAL HEALTH PROBLEM”
Thе misusе and ovеrusе of antibiotics havе еmеrgеd as onе of thе most prеssing global hеalth challеngеs of thе 21st cеntury. Antibiotics, oncе considеrеd miraclе drugs for trеating bactеrial infеctions, arе incrеasingly losing thеir еffеctivеnеss duе to inappropriatе prеscribing practicеs, sеlf-mеdication, incomplеtе trеatmеnt coursеs, and thеir widеsprеad usе in agriculturе and livеstock production. This misusе accеlеratеs thе dеvеlopmеnt of antimicrobial rеsistancе (AMR), a phеnomеnon in which microorganisms еvolvе mеchanisms to withstand thе drugs dеsignеd to kill thеm.
Antibiotic misusе; Antimicrobial rеsistancе (AMR); Global hеalth; Drug rеsistancе; Public hеalth challеngе; Ovеrusе of antibiotics; Sеlf-mеdication; Infеctious disеasеs; Hеalthcarе burdеn; Antibiotic stеwardship.
СОВРЕМЕННОЕ ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ СПРЕЕВ В ДИАГНОСТИКЕ И КОМПЛЕКСНОМ ЛЕЧЕНИИ ЭТМОИДИТА У ДЕТЕЙ
В данной научной статье анализируются современные подходы к диагностике и комплексному лечению этмоидита у детей. Этмоидит - это воспаление ячеек решетчатого лабиринта, которое часто встречается у детей в силу их анатомических особенностей и может протекать с осложнениями. Важную роль в ранней диагностике заболевания играют клинические признаки (заложенность носа, лихорадка, отёк в окологлазничной области), а также лабораторные и инструментальные исследования, включая рентгенографию и компьютерную томографию.
этмоидит, детская оториноларингология, синусит, интраназальные спреи, вазоконстрикторы, кортикостероидные спреи, растворы морской воды, комплексное лечение, диагностика, воспаление.
СОВРЕМЕННОЕ ПРИМЕНЕНИЯ ЛЕЧЕНИИ НАРУЖНЫХ ОТИТОВ ПИЯВКАМИ ИХ ЭФФЕКТИВНОСТЬ
В данной научной статье анализируются современные подходы к лечению наружного отита, в частности роль и эффективность гирудотерапии (лечения пиявками). Наружный отит представляет собой воспаление наружного слухового прохода, часто вызываемое бактериальной или грибковой инфекцией. К традиционным методам лечения относятся антибиотики, антисептические растворы и противовоспалительные препараты.
наружный отит, гирудотерапия, лечение пиявками, заболевания уха, воспаление, альтернативная медицина, биологически активные вещества, гирудин, комплексная терапия, эффективность лечения.
ORAL HEALTH STATUS IN PATIENTS DIAGNOSED WITH MALIGNANT NEOPLASMS
Cancer treatment, particularly cytotoxic chemotherapy and targeted therapy, is associated with a high incidence of oral complications such as mucositis, xerostomia, stomatitis, periodontal inflammation, and taste alterations. These complications can significantly impact patients’ quality of life and interfere with oncological treatment protocols.
oral mucositis, chemotherapy, cancer patients, periodontal disease, mucosal immunity, supportive care, photobiomodulation, cryotherapy, dental screening
HISTOLOGICAL FINDINGS IN PATIENTS WITH ACUTE GUTTATE PARAPSORIASIS
The paper presents the results of a histological study of 56 patients with acute guttate parapsoriasis. Characteristic morphological changes in the epidermis and dermis reflecting the inflammatory and immune nature of the disease were identified. The obtained data make it possible to уточнить diagnostic criteria and improve differential diagnosis with other dermatoses.
acute guttate parapsoriasis, histology, inflammation, epidermis, dermis
PHYTOCHEMICAL PROFILE AND HEPATOPROTECTIVE POTENTIAL OF ROSA CANINA, ORIGANUM TYTTANTHUM, AND CODONOPSIS CLEMATIDEA: A COMPREHENSIVE REVIEW
The prevalence of hepatic disorders worldwide necessitates the exploration of potent, bioavailable, and low-toxicity hepatoprotective agents derived from natural sources. Uzbekistan's diverse flora offers a rich repository of medicinal plants with largely untapped pharmacological potential. This review focuses on the phytochemical characterization and synergistic hepatoprotective effects of three distinct species: Rosa canina, Origanum tyttanthum, and the relatively understudied Codonopsis clematidea. Current evidence suggests that the integration of ascorbic acid-rich pseudo-fruits from R. canina, antioxidant-heavy polyphenols from O. tyttanthum, and the unique alkaloid and polysaccharide profile of C. clematidea could provide a superior therapeutic scaffold for liver regeneration. This article evaluates the biochemical mechanisms of these plants, discussing their impact on lipid peroxidation, enzyme activity, and membrane stabilization, ultimately proposing a scientific rationale for their formulation into a standardized dry extract-based dietary supplement.
Hepatoprotection, Rosa canina, Origanum tyttanthum, Codonopsis clematidea, Uzbekistan flora, Phytochemistry, Secondary metabolites, Dry extract technology.
APPLICATION OF RECOMBINANT DNA IN m=MEDICINE. MECHANISM OF ACTION OF DRUGS AGAINST VIRUSES AND TUMORS.
This article analyzes the application of recombinant DNA technology in medicine, as well as the mechanisms of action of drugs against viral infections and tumors. Recombinant DNA technology is one of the key areas of modern biomedicine, enabling the production of therapeutic proteins such as insulin, interferons, and vaccines. The paper also describes the mechanisms of antiviral drugs, which inhibit viral replication, and antitumor agents, which act by suppressing cell proliferation, inducing apoptosis, and blocking signal transduction pathways. The results of the study contribute to a deeper understanding of the significance and effectiveness of recombinant technologies in medical practice.
Recombinant DNA, genetic engineering, biotechnology, antiviral drugs, anticancer agents, cell proliferation, apoptosis, signal transduction pathways, vaccines, interferons.
ENDEMIC GOITER AND HYPOTHYROIDISM: PATHOGENESIS AND TREATMENT METHODS
This article discusses the etiology, pathogenesis, and modern treatment methods of endemic goiter and hypothyroidism. The mechanisms of development of endemic goiter caused primarily by iodine deficiency and its effects on the human body are analyzed. In addition, the clinical course of hypothyroidism, its impact on metabolic processes, and diagnostic approaches are reviewed. The article highlights effective therapeutic strategies, including iodine supplementation and hormone replacement therapy, and justifies their importance in treatment. The findings contribute to improving prevention and management of these diseases.
Endemic goiter, hypothyroidism, iodine deficiency, thyroid gland, thyroid hormones, thyroxine (T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH), metabolism, hormone therapy, iodine supplementation, prevention, diagnosis.
BOLALARNING ONTOLINGVISTIK QOBILIYATLARI MASALALARI
Insoniyat taraqqiyotining hozirgi bosqichida axborot oqimining shiddatli o‘sishi va ijtimoiy transformatsiyalar bolalarning intellektual va nutqiy rivojlanishiga bevosita ta’sir ko‘rsatmoqda. Transformatsion davr — bu nafaqat ijtimoiy-psixologik o‘zgarishlar, balki bolaning kognitiv funksiyalari yangi sifat bosqichiga ko‘tariladigan kritik palladir. Zamonaviy tilshunoslik va psixolingvistikaning eng ustuvor vazifalaridan biri — raqamli texnologiyalar va yangicha muloqot muhiti sharoitida bolalar nutqining ontogenezdagi rivojlanish qonuniyatlarini qayta anglashdan iborat. Maqolada bolalarda ontolingvistik qobiliyatlarini rivojlantirish tamoyillari va samarali omillari to‘g‘risida fikrlar yuritilgan.
ontolingvistik qobiliyat, bolalar nutqi, nutq rivojlanishi, ontogenez, kognitiv rivojlanish, raqamli texnologiyalar, ijtimoiy transformatsiya
NEW WAYS TO DETECT OSTEOPOROSIS EARLY IN YOUNG WOMEN BEFORE MENOPAUSE.
This means that just checking blood vitamin D or calcium might not show if bones are weak. The study suggests that looking at other markers and tools can help find osteoporosis early, especially in women who haven't gone through menopause yet. It’s important to check these risk factors early to keep bones healthy. Osteoporosis is a silent skeletal disease characterized by low bone mass and deterioration of bone microarchitecture, typically leading to increased fracture risk. While classically associated with postmenopausal estrogen deficiency, osteoporosis can also affect premenopausal women, especially when secondary factors such as vitamin D deficiency or endocrine disorders are present. Early diagnosis in premenopausal women is challenging because routine bone mineral density (BMD) screening is not usually performed in this age group. In this study, we analyzed data from 33 premenopausal women (mean age 44.9±2.4 years) to assess modern aspects of early detection. Femoral neck BMD (by DXA), T-score, Z-score, serum calcium, and 25-hydroxyvitamin D (cholecalciferol) were measured. Descriptive statistics (mean, SD, percentiles) are presented in Table 1.
Premenopausal women, osteoporosis , early diagnosis , bone mineral density
Summary Acne is one of the most common skin diseases that leads to persistent stigmatization and negatively affects the quality of life of patients. Currently, there are many treatments for this disease, but isotretinoin is the most effective against severe forms of acne and those cases where other forms of therapy have failed. Isotretinoin is an oral retinoid that has been used in clinical practice for about 40 years. This drug affects all the key links in the pathogenesis of acne, which determines its high effectiveness. Many clinical studies have been devoted to the study of the mechanisms of action of this drug, the specifics of its purpose, and undesirable side effects. Nevertheless, today, both patients and doctors have a number of misconceptions about the use of isotretinoin, which raises concerns about its administration, errors in treatment tactics, and low adherence to treatment. This article discusses the main issues about the mechanisms of action of isotretinoin, the specifics of its administration, indications and contraindications for use, undesirable side effects and ways to correct them, as well as the contradictions in the tactics of prescribing this drug that prevent its effective use. Special attention is paid to choosing the optimal therapeutic dose of isotretinoin and the duration of the course of treatment. In addition, the article discusses the main factors leading to failures in systemic retinoid therapy: slowing the onset of clinical response, the development of relapses after treatment, among which are the features of the course of the disease, the patient's age, his hormonal background, as well as the specifics of the dosage of the drug and the duration of its administration.
acne, isotretinoin, treatment, dosage, side effects
PERINATAL GIPOKSIYANING BOLALAR MARKAZIY NERV TIZIMIGA TA’SIRI
Ushbu maqolada perinatal gipoksiya natijasida yuzaga keladigan gipoksik-ishemik ensefalopatiyaning patogenezi, klinik belgilari, diagnostikasi va davolash usullari o‘rganildi. Namangan viloyat stomatologiya poliklinikasida 40 nafar bemor ishtirokida kuzatuv o‘tkazildi. Natijalar perinatal gipoksiya erta aniqlansa, asoratlar kamayishini ko‘rsatdi.
perinatal gipoksiya, GIE, yangi tug‘ilgan chaqaloq, nevrologiya, gipoksiya
INSON ORGANIZMIGA ZARAR KELTIRUVCHI PARAZITLAR, GELMINTLAR VA ULARNING TURLARI
Odam organizmida uchraydigan parazitlar keng tarqalgan bo'lib, jiddiy sog'liq muammolarini keltirib chiqarishi mumkin. Ushbu maqolada inson tanasida eng ko'p uchraydigan parazit turlari, ularning hayot sikllari va patogen ta'sirlari ko'rib chiqiladi. Asosan, protozoa va gelmintlar kabi parazitlar, ularning diagnostikasi va davolash usullari tahlil qilinadi. Tadqiqot inson salomatligini himoya qilishda parazitar kasalliklarning oldini olish va ularga qarshi kurashishning muhimligini ta'kidlaydi.
Parazitlar, Gelmintlar, Protozoa, Odam Salomatligi, Parazitar Kasalliklar, Diagnostika, Davolash, Oldini Olish
EARLY DETECTION AND MANAGEMENT OF MENSTRUAL AND OVARIAN DYSFUNCTION ASSOCIATED WITH THYROID DISORDERS IN REPRODUCTIVE-AGED WOMEN
Thyroid disorders are among the most prevalent endocrine conditions affecting women of reproductive age and are increasingly recognized as significant contributors to menstrual and ovarian dysfunction. Despite this, thyroid-related reproductive abnormalities remain underdiagnosed in gynecologic practice. Objective: This narrative review aims to synthesize current evidence on the pathophysiological mechanisms, clinical manifestations, early detection strategies, and management of menstrual and ovarian dysfunction associated with thyroid disorders in reproductive-aged women. Methods: A comprehensive narrative review was conducted using Scopus-indexed literature, including observational studies, clinical reviews, and international guidelines. Relevant studies examining the association between thyroid dysfunction and menstrual abnormalities, ovulatory disorders, ovarian reserve, and fertility outcomes were critically analyzed. Results: Thyroid dysfunction, particularly subclinical hypothyroidism, is highly prevalent among women presenting with abnormal uterine bleeding, with reported rates ranging from 20% to 44%. Menstrual irregularities may precede overt thyroid disease, highlighting their role as early clinical indicators. Thyroid dysfunction disrupts the hypothalamic–pituitary–ovarian axis, contributing to anovulation, altered ovarian reserve, and infertility.
thyroid dysfunction, menstrual disorders, abnormal uterine bleeding, ovarian dysfunction, ovulatory disorders, female infertility, polycystic ovary syndrome, thyroid autoimmunity.
“OVULYATOR DISFUNKSIYA BILAN BOG‘LIQ AYOLLAR BEPUSHTLIGINI DAVOLASHDA ANTIOKSIDANT TERAPIYANING AHAMIYATI”.
Ovulyator buzilishlar ayollarda bepushtlikning yetakchi sabablaridan biri hisoblanadi. So‘nggi yillarda tuxumdon faoliyatida oksidativ stressning ahamiyati tobora ortib bormoqda va antioksidant terapiya ovulyatsiya jarayonini yaxshilashda istiqbolli yondashuv sifatida qaralmoqda. Ushbu tadqiqotning maqsadi ovulyator buzilishi bilan kechuvchi bepusht ayollarda antioksidant terapiyaning klinik samaradorligini baholashdan iborat. Tadqiqot retrospektiv kuzatuvli dizaynda o‘tkazilib, 20 nafar ovulyator disfunktsiyali bepusht ayollarning tibbiy hujjatlari tahlil qilindi. Ovulyatsiya holati, dominant follikula shakllanishi va hayz siklining normallashuvi terapiyagacha va terapiyadan so‘ng solishtirildi. Statistik tahlilda Student t-testi va χ² testi qo‘llanildi. Antioksidant terapiya fonida ovulyatsiya aniqlanishi 24,4 foizdan 60,0 foizgacha oshgani statistik jihatdan ahamiyatli bo‘ldi (p < 0,05). Olingan natijalar antioksidant terapiya ovulyator disfunktsiyali bepusht ayollarda ovulyatsiya jarayonini yaxshilashda samarali yordamchi usul bo‘lishi mumkinligini ko‘rsatadi.
bepushtlik, ovulyator buzilish, ovulyatsiya, antioksidant terapiya, oksidativ stress.