International Bulletin of Medical Sciences and Clinical Research
International Bulletin of Medical Sciences and Clinical Research (ISSN-2750-3399) is an open access international peer reviewed german journal. IBMSCR publishes research monthly frequency basis. we explore your research worldwide by international Database indexings. we provide all articles crossref metadata link, google scholar, microsoft academic, Metadata Indexing and much more worldwide international indexings. Administer With Case Save Time With Automation 5000 Online Courses
Articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Under this license: Share: Copy and redistribute the material in any medium or format Adapt: Remix, transform, and build upon the material for any purpose, including commercially Attribution required: You must give appropriate credit, provide a link to the license, and indicate if changes were made. License URL: https://creativecommons.org/licenses/by/4.0/ Authors retain copyright of their work while granting the journal first publication rights.
XOFIZ TANISH BUXORIYNING “SHARAFNOMAYI SHOHIY” ASARIDAGI ANTROPONIMLARNING ETNIK KELIB CHIQISH TAHLILI
Ushbu maqolada XVI asrning buyuk tarixchi va adib Xofiz Tanish Buxoriyning «Abdullanoma» («Sharafnomai shohiy») nomli tarixiy-badiiy asarida uchraydigan shaxs nomlari — antroponimlar — etnik kelib chiqishiga ko'ra tahlil qilinadi va tasniflashtiriladi. Tadqiqotda turkiy, forsiy-tojik, arab, mo'g'ul va slavyan-rus guruhlarga mansub antroponimlar miqdoran va sifat jihatdan o'rganiladi. Natijalar shuni ko'rsatadiki, asardagi antroponimik landshaft Shayboniylar davri ko'p etnikli siyosiy muhitini to'liq aks ettiradi va Markaziy Osiyo onomastikasini o'rganishda muhim manba bo'lib xizmat qiladi.
Abdullanoma, Xofiz Tanish Buxoriy, antroponim, etnonim, onomastika, Shayboniylar, o'zbek tilshunosligi, nom tasnifi.
Copyright (c) 2026 https://creativecommons.org/licenses/by/4.0
HOFIZ TANISH BUXORIYNING “ABDULLANOMA” ASARI TIL XUSUSIYATLARI
Ushbu maqolada Xofiz tanish Buxoriyning “Abdullanoma”asarida keltirilgan etnonimlar o‘rganib chiqilgan. Ularning asrardagi ma’no va mavzu yuzasidan tahlili hamda ularning antroponimik jihatdan kelib chiqishi ilmiy manbalarga tayangan holda tahlil qilingan.
etnonim, antroponim, onomastika, “Abdullanoma”, leksik-semantik, ma’no-mazmun
SYNTHESIS OF ACETYLENE SERIES TRIOLS AND THEIR INVESTIGATION
This study is devoted to the synthesis of monoesters of acetylene triols as biologically active compounds and the investigation of their properties. The aim of the research was to obtain new compounds with practical and pharmacological significance. The monoesters were synthesized by condensation of 1-alkoxy-4-pentyn-2-ols with acetone under Favorskii reaction conditions. The reaction was carried out in liquid ammonia medium at low temperatures (from –35 to –40 °C) in the presence of potassium hydroxide. As a result, six new monoester derivatives of acetylene triols were obtained. It was established that the structure of the alkyl radical significantly affects the yield of the final products. Higher yields were observed for methyl and ethyl derivatives, whereas the yield decreased with increasing alkyl chain length. The almost complete absence of by-products indicates the high selectivity of the reaction. The structure and purity of the synthesized compounds were confirmed by thin-layer chromatography (TLC), IR spectroscopy, and elemental analysis. Characteristic absorption bands corresponding to OH, C≡C, and C–O–C groups were identified in the IR spectra.
REGENERATIVE PROPERTIES OF PHARMACEUTICAL CREAMS BASED ON CARTHAMUS TINCTORIUS L. EXTRACT: PHARMACOLOGICAL MECHANISMS OF ACTION AND FUTURE PERSPECTIVES
Carthamus tinctorius, commonly known as safflower, has attracted increasing scientific interest due to its diverse pharmacologically active compounds and broad therapeutic potential in topical pharmaceutical formulations. The plant is rich in flavonoids, phenolic compounds, polyunsaturated fatty acids, hydroxysafflor yellow A, and other bioactive constituents exhibiting antioxidant, anti-inflammatory, antimicrobial, and tissue-regenerative activities. In recent years, pharmaceutical creams containing Carthamus tinctorius L. extract have emerged as promising candidates for the management of skin injuries, inflammatory dermatoses, burns, chronic wounds, and cosmetic skin regeneration.
Carthamus tinctorius L.; safflower extract; pharmaceutical cream; wound healing; skin regeneration; antioxidant activity; anti-inflammatory activity; flavonoids; topical formulation; regenerative dermatology.
ADVANTAGES OF CASE STUDIES TO ENHANCE COMMUNICATION SKILLS IN THE MEDICAL FIELD
This article highlights the importance of the case study method in developing communication skills within the medical field. In medical practice, effective communication between a doctor and a patient is a crucial factor in accurately diagnosing illnesses, organizing the treatment process, and earning the patient's trust. Case studies enable students to analyze real clinical situations, make decisions in problematic circumstances, work in a team, and develop professional communicative competencies. This method also serves to cultivate students' critical thinking, empathy, and listening skills. The article analyzes the advantages of the case study method and its effectiveness in the medical education process.
medical education, communication skills, case study, communicative competence, clinical situation, doctor-patient relationship, interactive education, critical thinking, empathy, medical pedagogy.
DEVELOPMENTAL STAGES OF TASTE AND OLFACTORY ANALYZERS IN CHILDREN WITH VISUAL IMPAIRMENTS ON THE BASIS OF INTEGRATED EDUCATION
The article explores the developmental peculiarities of taste and olfactory analyzers in children with visual impairments within the framework of integrated education. While vision serves as the dominant sensory modality in most children, visual deficits significantly transform the functional organization of compensatory sensory systems, particularly taste and smell. The study highlights the theoretical and methodological foundations of multisensory integration, focusing on how the absence or limitation of visual input enhances the reliance on gustatory and olfactory channels for cognitive, emotional, and social development. By analyzing neuropsychological and pedagogical literature, the paper demonstrates that taste and olfactory analyzers develop through distinct stages, each of which is influenced by educational context, social interaction, and the availability of sensory-rich learning environments. The paper further argues that integrated education creates favorable conditions for stimulating sensory plasticity, thereby fostering more effective adaptive mechanisms in visually impaired children. These findings contribute to the growing discourse on inclusive pedagogy and developmental psychology by underscoring the importance of integrative approaches in enhancing the sensory development of children with visual impairments.
Integrated education; visual impairment; taste analyzer; olfactory analyzer; sensory development; multisensory integration; compensatory mechanisms; inclusive pedagogy.
THE ROLE OF AI TOOLS IN PROMOTING AUTONOMY, MOTIVATION, AND INDEPENDENT LEARNING AMONG UNIVERSITY STUDENTS
The rapid integration of artificial intelligence (AI) tools into higher education has generated considerable scholarly interest in their capacity to transform traditional learning paradigms. This article examines the role of AI-powered tools — including intelligent tutoring systems, adaptive learning platforms, virtual assistants, and AI-driven feedback mechanisms — in fostering learner autonomy, enhancing academic motivation, and supporting independent learning among university students. Employing a systematic review methodology, the study synthesises evidence from peer-reviewed literature published between 2016 and 2024. Findings indicate that AI tools significantly support self-regulated learning behaviours, increase intrinsic motivation through personalised feedback, and reduce dependence on instructor-led instruction when implemented thoughtfully. However, effective outcomes are contingent upon institutional support, digital literacy, and pedagogically sound design. The article concludes with implications for educators and policymakers seeking to leverage AI responsibly in higher education contexts.
artificial intelligence in education, learner autonomy, academic motivation, independent learning, self-regulated learning, higher education, intelligent tutoring systems, adaptive learning
THE RELATIONSHIP BETWEEN LEARNING STYLES AND VOCABULARY ACHIEVEMENT IN PRIMARY SCHOOL
Vocabulary acquisition represents a foundational pillar of literacy development in primary education, yet students exhibit markedly different patterns of lexical growth depending on their dominant learning styles. This article investigates the relationship between individual learning styles — visual, auditory, kinaesthetic, and read/write — and vocabulary achievement among primary school learners. Drawing on a mixed-methods research design involving 120 students aged 7–11 across three primary schools in Fergana region, the study employs both standardised vocabulary assessments and learning style inventories. Quantitative findings reveal statistically significant correlations between specific learning styles and vocabulary test performance, while qualitative data illuminate the instructional strategies that best accommodate each learner profile. Results indicate that visual and read/write learners consistently outperform peers in written vocabulary tasks, whereas kinaesthetic learners demonstrate stronger performance in contextually embedded vocabulary activities. The article concludes with evidence-based pedagogical recommendations for primary school teachers seeking to differentiate vocabulary instruction in alignment with diverse learner needs.
learning styles, vocabulary acquisition, primary education, VARK model, differentiated instruction, lexical development, English language teaching
KNOWLEDGE AND POWER IN RENAISSANCE DRAMA: MARLOWE AND SHAKESPEARE
This article examines the interplay of knowledge and power in Christopher Marlowe's Doctor Faustus (c. 1592) and William Shakespeare's The Tempest (1611). Drawing on New Historicist and Foucauldian frameworks, it argues that both playwrights construct knowledge not merely as intellectual achievement but as a contested site of political authority, social control, and transgression. Faustus's pursuit of forbidden knowledge reflects Elizabethan anxieties about humanism and damnation, while Prospero's mastery of learning consolidates colonial and patriarchal dominion. The analysis reveals how Renaissance drama encodes the ideological tensions of its era.
Renaissance drama, knowledge and power, Doctor Faustus, The Tempest, Christopher Marlowe, William Shakespeare, New Historicism, humanism, colonialism, transgression.
ASSESSMENT OF BONE TISSUE CONDITION DURING DENTAL IMPLANTATION IN PATIENTS WITH SOMATIC DISEASES
The issue of dental implantation in patients with chronic somatic diseases is becoming increasingly important in modern dental practice. The increase in life expectancy, the growing prevalence of endocrine, cardiovascular, and metabolic disorders, as well as age-related changes in bone tissue, necessitate a more thorough preparation of patients for implant treatment. Particular attention is paid to the condition of bone metabolism, since disturbances in bone remodeling processes may affect implant osseointegration and the course of the postoperative period. In this regard, the study of indicators characterizing bone tissue condition, as well as factors contributing to the development of complications during dental implantation, remains highly relevant. A comprehensive assessment of the structural and functional characteristics of bone tissue makes it possible to determine preventive strategies and optimize the management of patients with concomitant somatic pathology.
dental implant, somatic pathology, somatic diseases, osteopenia, osteoporosis. markers of osteogenesis, calcium-regulating hormones, densitometry.
“IMPROVING COMPREHENSIVE TREATMENT MEASURES FOR THE PREVENTION OF PERI-IMPLANTITIS IN PATIENTS WITH DENTAL IMPLANTS.”
This article discusses modern approaches to the prevention of periimplantitis in patients with dental implants through comprehensive therapeutic and preventive measures. Based on recent scientific literature, the etiological factors, microbial biofilm formation, inflammatory reactions of peri-implant tissues, and risk factors associated with peri-implantitis are analyzed. Special attention is given to the role of professional oral hygiene, antibacterial therapy, bioactive materials, and modern implant surface technologies such as SLA, Xpeed, and X- ctive in improving implant survival and peri-implant tissue health. The effectiveness of combined treatment strategies aimed at reducing inflammation, enhancing osseointegration, and preventing bone loss around implants is also highlighted
dental implants, periimplantitis, orthopedic dentistry, osseointegration, biofilm, peri-implant tissues, prevention, SLA surface, Xpeed technology, Xи Active implants, bioactive materials, oral hygiene.
MINIMALLY INVASIVE DECOMPRESSION USING THE UBE TECHNIQUE FOR DEGENERATIVE SPINAL STENOSIS ASSOCIATED WITH SPECIFIC AND NON-SPECIFIC INFLAMMATION
Most researchers use the term "spinal canal stenosis" to describe symptoms caused by anatomical narrowing of the spinal canal. Specific and nonspecific spondylodiscitis is, in the modern sense, edema of the bone marrow and bacterial inflammation in two adjacent vertebrae and the intervertebral disc located between them.
UBE technique, specific and nonspecific inflammation, lumbar spine, decompression.
ОПТИМИЗАЦИЯ АЛГОРИТМОВ РАННЕГО ВЫЯВЛЕНИЯ СУБКЛИНИЧЕСКИХ АРИТМОГЕННЫХ СОСТОЯНИЙ У ВОЕННОСЛУЖАЩИХ НА ОСНОВЕ ЦИФРОВОГО ЭЛЕКТРОКАРДИОГРАФИЧЕСКОГО СКРИНИНГА И СТРАТИФИКАЦИИ РИСКА ВНЕЗАПНЫХ СЕРДЕЧНЫХ СОБЫТИЙ
Субклинические аритмогенные состояния представляют серьёзную проблему современной военной медицины, поскольку ассоциируются с повышенным риском внезапных сердечных событий у практически здоровых военнослужащих. Стандартные методы кардиологического обследования не всегда позволяют своевременно выявлять скрытые электрофизиологические нарушения, особенно у лиц без клинических проявлений. Использование цифровых электрокардиографических технологий и современных алгоритмов стратификации риска способствует повышению эффективности ранней диагностики сердечно-сосудистых нарушений.
цифровая электрокардиография, аритмогенные состояния, военнослужащие, внезапная сердечная смерть, кардиологический скрининг, стратификация риска, субклинические аритмии.
ANTIMICROBIAL ACTIVITY OF 6-AMINOPURINE DERIVATIVES ENCAPSULATED IN NANOSTRUCTURED HYDROGELS
Nanostructured hydrogels are widely investigated as advanced drug delivery systems due to their high biocompatibility, large water content, and controlled release properties. Incorporation of biologically active purine derivatives such as 6-aminopurine into hydrogel matrices may enhance antimicrobial activity while maintaining a moist environment suitable for tissue regeneration. The present study investigates the antimicrobial activity of 6-aminopurine derivatives encapsulated in nanostructured hydrogels against several pathogenic microorganisms. The results demonstrated that the hydrogel system provided sustained release of the active compound and significantly inhibited microbial growth compared with the control samples. These findings suggest that nanostructured hydrogel systems containing purine derivatives may serve as promising antimicrobial materials for biomedical and pharmaceutical applications.
nanostructured hydrogel, 6-aminopurine derivatives, antimicrobial activity, controlled release, biomedical materials.
MAHALLIY POMIDOR NAVLARINING QURITISHGA MOSLIGI VA ULARNING BIO-KIMYOVIY TAHLILI
Ushbu maqolada O‘zbekiston sharoitida yetishtiriladigan mahalliy pomidor (Solanum lycopersicum L.) navlarining quritish sanoatiga mosligi va ularning quritishdan oldingi hamda keyingi bio-kimyoviy ko‘rsatkichlari tadqiq etilgan. Izlanishlar davomida navlarning quruq modda miqdori, umumiy shakar, kislotalilik darajasi, vitamin C (ascorbin kislotasi) hamda likopin miqdori tahlil qilindi. Natijalar shuni ko‘rsatadiki, quruq modda miqdori yuqori va eti go‘shtli bo‘lgan mahalliy navlar quritilgan mahsulot tannarxini kamaytirish va sifatini oshirishda yuqori samaradorlikka ega.
pomidor, quritish, bio-kimyoviy tahlil, quruq modda, likopin, vitamin C, saqlash, qayta ishlash.
АNESTEZIOLOGIYA VA REANIMATSIYA BO`LIMI KATTA HAMSHIRASI FAOLIYATINING O`ZIGA XOS JIHATLARI.
Mazkur maqolada anesteziologiya va reanimatsiya bo‘limida faoliyat yurituvchi katta hamshiraning kasbiy vazifalari, mas’uliyat darajasi va tibbiy jamoada tutgan o‘rni yoritib berilgan. Bo‘limning o‘ziga xos xususiyati shundaki, u yerda hayot uchun xavfli bo‘lgan holatdagi bemorlar bilan ishlanadi, bu esa katta hamshiradan yuqori darajadagi tayyorgarlik, muvofiqlashtirish qobiliyati va tezkor qaror qabul qilishni talab etadi. Maqolada katta hamshiraning diagnostik va davolovchi muolajalarni muvofiqlashtirishdagi roli, bemor parvarishini tashkil etish, yosh hamshiralarga rahbarlik qilish hamda reanimatsion uskunalarning texnik tayyorgarligini nazorat qilish kabi jihatlar tahlil qilingan. Shuningdek, maqolada zamonaviy davrda kasbiy kompetensiyalarni rivojlantirish, stressga bardoshlilik va jamoaviy ishning ahamiyati haqida ham fikr yuritilgan.
anesteziologiya, reanimatsiya, katta hamshira, bemor parvarishi, hayotiy funksiyalarni tiklash, reanimatsion yordam, kasbiy kompetensiya, sog‘liqni saqlash jamoasi, favqulodda holat, tibbiy muvofiqlashtirish, stressga bardoshlilik.
КЛИНИЧЕСКОЕ ТЕЧЕНИЕ ВНЕБОЛЬНИЧНОЙ ПНЕВМОНИИ У ДЕТЕЙ И ЕЁ СВЯЗЬ С НУТРИТИВНЫМ СТАТУСОМ
Внебольничная пневмония остаётся одной из ведущих причин заболеваемости и смертности среди детей во всём мире. В статье анализируются клинические особенности течения заболевания в зависимости от нутритивного статуса ребёнка. Белково-энергетическая недостаточность, дефицит микронутриентов (витамины A, D, цинк, железо) и хроническое недоедание существенно утяжеляют клиническое течение пневмонии, удлиняют сроки выздоровления, повышают частоту осложнений и риск длительной гипоксемии и дыхательной недостаточности. Представлены современные данные о влиянии нутритивной недостаточности на иммунный ответ, скорость рентгенологического разрешения и исход заболевания. Особое внимание уделяется важности ранней нутритивной оценки и своевременной нутритивной поддержки в комплексном лечении внебольничной пневмонии у детей. Улучшение нутритивного статуса рассматривается не только как лечебная, но и как профилактическая стратегия в снижении бремени пневмонии в детской популяции.
внебольничная пневмония, дети, нутритивный статус, белково-энергетическая недостаточность, дефицит микронутриентов, клиническое течение, иммунный ответ, осложнения, педиатрическая пневмония
THE POSITION OF HELICHRYSUM SPECIES IN “FLORA OF UZBEKISTAN” AND THEIR ANALYSIS, CASE STUDY OF HELICHRYSUM NURATAVICUM
This article provides an overview of Helichrysum nuratavicum Krasch, an endemic species in Uzbekistan, belonging to the Helichrysum genus within the Asteraceae family. It discusses the significance of genus, with a focus on its medicinal properties and the plant's habitat in the Pamiro-Alai region, found in wormwood-grass thickets at altitudes of 1,500 to 2,000 meters. The article highlights the importance of further research on this species, as its medicinal benefits and unique endemic nature make it a valuable subject for scientific study and conservation efforts.
Helichrysum nuratavicum, medicinal plant, endemic, Flora of Uzbekistan, Flora USSR.
«MODERN TREATMENT AND REHABILITATION OF SPINAL FRACTURES»
Spinal cord injury (SCI) is defined as impairment in the brainstem/cortex and spinal neurons between the ascending and descending neural pathways, leading to a loss in sensory-motor functions.
Combination therapy, Neural tissue engineering, Neuron, SCI, Spinal cord injury.
DISTAL FEMUR FRACTURES AND THEIR TREATMENT
The goal of this study was to provide an update on the management of these fractures. The basic points of treatment are summarized. The technical details and the indications of the different surgical treatments are then described. Finally, recent radiological, clinical and biomechanical results published in the literature are reported to compare the techniques
distal femur, fracture, supracondylar and intercondylar fracture, internal fixation, biomechanics
JUDICIAL POWER IN THE REPUBLIC OF UZBEKISTAN LEGAL MECHANISMS FOR ENSURING
This article provides a comprehensive analysis of the legal mechanisms for ensuring the independence of the judicial power in the Republic of Uzbekistan. The author examines the constitutional foundations of judicial independence, the procedure for appointing and dismissing judges, guarantees of financial independence, and mechanisms for applying disciplinary measures to the judiciary. It also examines the role of the Supreme Judicial Council, its compliance with international standards, existing problems, and ways to address them. The article is of great practical and theoretical importance in the context of the ongoing judicial and legal reforms in Uzbekistan.
judicial independence, legal mechanisms, judicial council, constitutional guarantees, judicial and legal reform, Uzbekistan.
THE ROLE OF ARTIFICIAL INTELLIGENCE IN TUMOR DIAGNOSIS
Artificial intelligence is becoming an important tool in tumor diagnostics, increasing the accuracy and speed of early-stage pathology detection. Machine learning algorithms can analyze medical images and large clinical data sets, reducing the likelihood of diagnostic errors and assisting physicians in decision-making. The use of such technologies is particularly relevant given the rising incidence of cancer and the time constraints of specialists. This article examines the current capabilities of artificial intelligence in cancer diagnostics, its advantages and limitations, and the prospects for its implementation in clinical practice.
Artificial intelligence, tumor diagnostics, oncology, machine learning, medical imaging.
ADAPTIVE CONTROL MODELS FOR HUMAN-ROBOT COLLABORATIVE SYSTEMS IN LEAN WAREHOUSING: A CYBER-PHYSICAL APPROACH TO INDUSTRY 5
The transition from Industry 4.0 to Industry 5.0 necessitates a shift from purely autonomous automation to human-centric collaborative systems. While previous frameworks such as Dy- namic Value Stream Mapping (DVSM) successfully utilized IIoT data to quantify process waste, current collaborative environments suffer from "safety-induced latency"—where robots operate at suboptimal fixed speeds or stop entirely in the presence of humans. This paper proposes a novel Adaptive Control Model (ACM) that leverages a Cyber-Physical System (CPS) to synchronize robot trajectories with real-time human biometric and positional data. By modeling the warehouse floor as a dynamic Markov Decision Process, we implement a Deep Reinforcement Learning agent that adjusts robot velocity and proximity buffers based on predicted human intent and fatigue levels. Empirical validation through a high-frequency kitting simulation demonstrates that this adaptive approach reduces non-value-added (NVA) "hesitation time" by 22.0 % while maintaining ISO-compliant safety standards. This research provides a prescriptive roadmap for Lean Warehousing, transforming the value stream into a self-adjusting, ergonomic, and highly efficient collaborative ecosystem.
INTERNATIONAL EXPERIENCES IN THE MODERN PRESCHOOL EDUCATION SYSTEM: REGGIO EMILIA APPROACH
This article analyzes the best international practices used in the modern preschool education system, specifically the theoretical foundations and practical implications of the Reggio Emilia approach. The article highlights the role of this approach in the development of a child's personality, its impact on the development of creativity, independent thinking, and communication skills. It also highlights the key principles of the Reggio Emilia method—viewing the child as the central subject, the role of the environment in education, and collaboration between parents and educators. The possibilities of integrating this approach into the national preschool education system are also discussed.
preschool education, Reggio Emilia approach, international experience, child development, creativity, educational environment, pedagogical collaboration, innovative methods, student-centered education, education system.
ANIQ INTEGRALNING IQTISOD, BIOLOGIYADAGI TATBIQLARI
Ushbu maqola aniq integralning iqtisodiyot va biologiya sohalaridagi keng qamrovli tatbiqlarini o'rganadi. Iqtisodiyotda aniq integral iste'molchi va ishlab chiqaruvchi profitsiti, umumiy xarajatlar va daromadlar, shuningdek, kapital shakllanishi kabi muhim iqtisodiy ko'rsatkichlarni tahlil qilishda qo'llaniladi. Biologiyada esa populyatsiya o'sishi modellari, dori vositalarining organizmdagi konsentratsiyasi va qon oqimi tezligini hisoblashda muhim rol o'ynaydi. Maqola ushbu fanlararo yondashuv orqali matematik vositalarning real dunyo muammolarini hal qilishdagi ahamiyatini ko'rsatadi.
Aniq Integral, Tatbiqlar, Iqtisodiyot, Biologiya, Iste'molchi Profitsiti, Populyatsiya O'sishi, Matematik Modellashtirish, Fanlararo Tadqiqotlar
PRINCIPLES OF BIOLOGICAL SYNERGY IN THE STRUCTURAL ORGANIZATION OF KHOREZM JEWELRY COMPLEXES
This article analyzes the centuries-old history of the development of Khorezmian jewelry art, the evolution of its artistic style, and the structural features of its jewelry items. The harmony of vegetable and biological forms used in jewelry complexes (shokila, peshkhalta), as well as their aesthetic and socio-cultural significance, are revealed from a scientific perspective.
jewelry, Khorezm, shokila, peshkhalta, synergy, ornament, aesthetic function, harmony of materials.
MODERN ANALYTICAL APPROACHES FOR STANDARDIZATION OF “VIGITRIL” SUSPENSION BASED ON BISMUTH AND HISTIDINE
This article presents a comprehensive pharmaceutical and analytical investigation of “Vigitril” suspension developed on the basis of bismuth, histidine, and ethylenediaminetetraacetic acid. The study focuses on modern methods of standardization, physicochemical characterization, quality assessment, and stability evaluation of the suspension dosage form. Modern spectrophotometric and chromatographic methods were applied for qualitative and quantitative determination of active pharmaceutical ingredients. Particular attention was devoted to validation parameters including specificity, precision, repeatability, and linearity of analytical procedures. The obtained results demonstrated that the developed suspension possesses satisfactory physicochemical stability, low toxicity, and promising therapeutic effectiveness. The study confirms the pharmaceutical potential of “Vigitril” suspension as a перспективный gastroprotective preparation suitable for further industrial development and clinical application.
bismuth, histidine, suspension, standardization, spectrophotometry, chromatography, pharmaceutical analysis, Helicobacter pylori, gastroprotective preparations
OPTIMIZATION OF PHARMACEUTICAL TECHNOLOGY FOR COMBINED ANTIDIABETIC PREPARATIONS IN UZBEKISTAN
The rapid increase in diabetes mellitus cases in Uzbekistan has created a need for innovative pharmaceutical solutions capable of improving therapeutic effectiveness and reducing treatment-related complications. Combined antidiabetic preparations containing herbal components and synthetic active substances have become an important direction in pharmaceutical research due to their multifunctional pharmacological activity. The present article analyzes pharmaceutical technological approaches aimed at optimizing the production of combined antidiabetic medicines in Uzbekistan. The study focuses on innovative extraction methods, granulation technologies, bioavailability enhancement, and stabilization of active compounds in combined dosage forms. Particular attention is devoted to local medicinal plants with hypoglycemic potential and their incorporation into modern pharmaceutical formulations. The findings demonstrate that technological optimization significantly improves product stability, dissolution properties, and pharmacological efficiency.
combined antidiabetic preparations, pharmaceutical optimization, medicinal plants, granulation technology, bioavailability, Uzbekistan, diabetes mellitus
STUDY OF THE PROSPECTS FOR DEVELOPING ANTIDIABETIC PHYTOPREPARATIONS BASED ON LOCAL MEDICINAL PLANTS OF UZBEKISTAN
Diabetes mellitus remains one of the most significant medical and social problems worldwide. The increasing prevalence of type 2 diabetes in Uzbekistan creates the need for the development of effective, affordable, and safe antidiabetic medicines. In recent years, particular attention has been paid to herbal medicines due to their relatively low toxicity, availability, and complex pharmacological activity. Uzbekistan possesses rich reserves of medicinal plants with potential hypoglycemic properties, including licorice, milk thistle, rosehip, barberry, and chicory. This article investigates the prospects for developing antidiabetic phytopreparations based on local medicinal plants and evaluates their technological potential in pharmaceutical production. The study analyzes scientific literature, pharmacognostic characteristics, extraction technologies, and pharmaceutical forms suitable for antidiabetic herbal preparations. The results indicate that the use of local plant raw materials can contribute to the development of import-substituting medicines and improve pharmaceutical independence in Uzbekistan. Particular attention is paid to the technological processes involved in obtaining dry extracts and producing solid dosage forms.
diabetes mellitus, phytopreparations, medicinal plants, pharmaceutical technology, Uzbekistan, dry extracts, antidiabetic activity, herbal medicines
Desquamative glossitis is a chronic, recurrent and benign inflammatory disorder of the tongue, most often referred to as geographic tongue or benign migratory glossitis. The term “geographic” reflects the visual appearance of the lesions: smooth red areas with irregular white or yellowish borders resemble a map. These lesions may disappear in one area and reappear in another, which explains the word “migratory” in the alternative clinical name. StatPearls describes geographic tongue as a benign chronic relapsing inflammatory condition of unknown etiology, usually presenting as erythematous migratory circinate patches that create a map-like pattern [1].